Enzybiotics

Enzybiotics are an experimental antibiotic approach employing enzymes to combat pathogenic bacterial infections. The name is a portmanteau of the words "enzyme" and "antibiotics" first coined in March 2001 by Nelson et al.[1] Many of the enzymes used as enzybiotics are lysins, enzymes derived from bacterial viruses (or bacteriophages) used to release progeny bacteriophage from infected bacteria, though other natural or synthetic enzymes may be used.[2][3]

Phage-derived enzymes

Enzybiotic approaches have attempted to incorporate bacteriophage-derived lysins to kill bacterial cells.[4][5] One particular lysin, isolated from phage P68 of Staphylococcus aureus, has shown antimicrobial activity against its host species when used along with the antibiotic gentamicin.[6]

See also

References
  1. Nelson, D; Loomis, L; Fischetti, VA (March 2001). "Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme". Proceedings of the National Academy of Sciences. 98 (7): 4107–12. Bibcode:2001PNAS...98.4107N. doi:10.1073/pnas.061038398. PMC 31187. PMID 11259652.
  2. Veiga-Crespo, P; Ageitos, JM; Poza, M; Villa, TG (August 2007). "Enzybiotics: a look to the future, recalling the past". Journal of Pharmaceutical Sciences. 96 (8): 1917–24. doi:10.1002/jps.20853. PMID 17518365.
  3. Veiga-Crespo, P. and Villa, T. G. (2009) Phylogeny of Enzybiotics, in Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics (eds T. G. Villa and P. Veiga-Crespo), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi:10.1002/9780470570548.ch4
  4. Hermoso, JA; García, JL; García, P (October 2007). "Taking aim on bacterial pathogens: from phage therapy to enzybiotics". Current Opinion in Microbiology. 10 (5): 461–72. doi:10.1016/j.mib.2007.08.002. hdl:10261/62610. PMID 17904412.
  5. Pastagia, M; Schuch, R; Fischetti, VA; Huang, D. (October 2013). "Lysins: the arrival of pathogen-directed anti-infectives". Journal of Medical Microbiology. 62: 1506–15. doi:10.1099/jmm.0.061028-0. PMID 23813275.
  6. Manoharadas, S; Witte, A; Bläsi, U (2009-01-01). "Antimicrobial activity of a chimeric enzybiotic towards Staphylococcus aureus". Journal of Biotechnology. 139 (1): 118–23. doi:10.1016/j.jbiotec.2008.09.003. PMID 18940209.


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