Empatica

Empatica Inc. is an American healthcare company that was a spinoff of MIT Media Lab in Cambridge, MA.[1] It makes medical-grade wearable technology and software for the collection and interpretation of physiological data[2] such as heart rate variability, electrodermal activity, acceleration and movement, skin temperature, and autonomic arousal.[3]

Empatica Inc.
Private
IndustryHealthcare
Founded2013
FounderMatteo Lai

Maurizio Garbarino

Rosalind Picard

Simone Tognetti
HeadquartersBoston, MA
ProductsEmbrace2

E4 Wristband

EmbracePlus

Research Portal

Empatica Care

Alert App

Mate App
ServicesSeizure Monitoring
Websiteempatica.com

Uses include alerting epilepsy patients of oncoming generalized tonic-clonic seizures.[4] The E4 is used by researchers for real-time physiological data capture.

The company is headquartered in Boston with offices in Milan and Seoul.  

History

Empatica Inc. was founded in 2013 in Cambridge, MA, by Matteo Lai, Simone Tognetti, Maurizio Garbarino and Rosalind Picard. Picard serves as part-time Chief Scientist and Chairman of the board, while Lai is full-time CEO, Tognetti is CTO, and Garbarino is CSA.

In 2014, in partnership with The Epilepsy Foundation, Empatica launched a crowdfunding campaign on Indiegogo for the creation of a wrist-worn device for monitoring and alerting to grand mal seizures, and help reduce cases of Sudden Unexpected Death in Epilepsy (SUDEP).[5][6] This device was called Embrace.

In January 2018 Embrace (both the hardware and its Alert software) received FDA-clearance for adults and became the first medical wristwatch to be cleared by FDA for use in Epilepsy.[4] In November 2018 an updated version of the Embrace, called Embrace2, was released.[7]

In January 2019, Embrace2 received FDA-clearance for children ages 6 and up.[8]

In May 2020, Empatica launched Empatica Care [9], a remote health monitoring platform that comprises of the Empatica E4 wearable, an online data visualization dashboard, and a mobile phone application. The platform enables the real-time and continuous measurement of respiration rate, heart rate, peripheral temperature, and heart rate variability.

Collaborations

Empatica is working in partnership with the U.S. Government's BARDA Division of Research, Innovation and Ventures (DRIVe), under the Department of Health and Human Services (HHS), to collaborate on the development of a new smart watch which will alert users when they are developing a serious respiratory infection, before any symptoms appear.[10]

In June 2020, Empatica renewed its partnership with HHS[11] to validate an algorithm that analyzes vital signs collected via Empatica's sensors to provide an early indication of whether an individual has a high risk of developing a COVID-19 infection.

Empatica also partnered with Japanese multinational information and network technology company NEC in a health study to help Japanese employees measure their stress levels, as a response to the phenomenon of karoshi.[12]

Products

Embrace2

Chief Scientist and co-founder Rosalind Picard and her colleagues at the MIT Media lab were working on a wristband to help children on the autism spectrum better communicate their emotional states. One of Picard’s undergraduate students borrowed a couple devices to bring home over the winter break and test them on his autistic brother. A spike in activity registered by one of the devices during this time, attributed to a grand mal seizure event, tipped Picard off to the technology’s potential for seizure detection. [5][13]

The company evolved the device as a smart watch to detect generalized tonic-clonic seizures and alert caregivers in real time via a companion app.[14] The mobile app and subscription service sends out an emergency call and text message to listed caregivers, including their exact GPS location.[15]

Embrace is also used by researchers, pharmaceutical businesses, and other healthcare investigators to collect medical quality data for research. In 2017, Sunovion used Embrace in a phase 4 clinical study of Aptiom, a drug meant to reduce seizures in people with epilepsy.[16] In 2018, results were published showing that data collected by Embrace was useful in examining the nausea felt by passengers undergoing zero-gravity flight.[17]

A second mobile app called 'Mate' displays sleep time, efficiency, fragmentation, and tosses and turns, as well as levels of physical activity and step count recorded by the smartwatch. It can also be used as a digital seizure diary.[18]

A cloud-based research portal enables researchers to virtually view and process the raw data collected by the watch during their studies.

E4 Wristband

The E4 collects real-time physiological data, which can be used to conduct in-depth analysis and visualization.[19] The device is equipped with a PPG sensor, EDA sensor, 3-axis accelerometer, and Infrared Thermopile, and can be used by researchers to measure arousal in individuals within laboratory and/or naturalistic settings to study, for example, stress or other emotions.[3] Studies conducted using the E4 range from testing wearables for predicting substance addition relapses,[20] to measuring the engagement of students in a classroom,[21] to researching predictions in aggressive meltdowns in autism.[22]

EmbracePlus

In November 2019, Empatica announced EmbracePlus,[23] a research smart watch which is built in partnership with the Translational Research Institute for Space Health (TRISH), under NASA’s Human Research Program (HRP) which develops innovative approaches to reduce risks to humans on deep space missions, including NASA’s Journey to Mars.[24]

Digital Biomarkers

Empatica develops physiological and behavioral digital biomarkers for non-invasive patient monitoring and diagnostics purposes. These include convulsive seizure detection[25], suicidal behavior[26], and influenza [27].

References
  1. "Empatica". MIT Media Lab. Retrieved 2020-03-02.
  2. "Beyond Fitbit: The quest to develop medical-grade wearables". Reuters. 2015-12-18. Retrieved 2020-03-02.
  3. "Empatica Wristband - Social Lab - Universiteit Antwerpen". www.uantwerpen.be. Retrieved 2020-03-02.
  4. "Empatica's consumer-facing epileptic seizure-detecting wearable gets FDA clearance". MobiHealthNews. 2018-02-05. Retrieved 2020-03-02.
  5. Picard, Rosalind, An AI smartwatch that detects seizures, retrieved 2020-03-02
  6. "Empatica crowdfunding Embrace, a wearable for epilepsy". MobiHealthNews. 2015-01-07. Retrieved 2020-03-02.
  7. "Empatica launches latest generation Embrace 2 for epilepsy management". Gadgets & Wearables. 2018-12-06. Retrieved 2020-03-02.
  8. "FDA Clears Embrace Epilepsy Smartband for Pediatric Use". HCPLive®. Retrieved 2020-03-02.
  9. "A guide to connected health device and remote patient monitoring vendors". Healthcare IT News. Retrieved 2020-06-16.
  10. "Empatica Partners With DRIVe to Develop Smart Watch That Predicts Lung Infections Before Symptoms Appear". BioSpace. Retrieved 2020-03-02.
  11. "Empatica and BARDA Join Forces to Validate Wearable System That Detects COVID-19 Before Symptoms Appear". PRNewswire. Retrieved 2020-06-19.
  12. Desk, AIT News (2019-11-14). "Embrace2 by Empatica Used by NEC in Revolutionary Employee Health Study". AiThority. Retrieved 2020-03-02.
  13. Grossman, Lisa. "Sweat-sensing bracelet could detect fatal seizures". New Scientist. Retrieved 2020-03-02.
  14. Stinson, Liz (2014-12-01). "A Next-Level Smartwatch That Detects Seizures". Wired. ISSN 1059-1028. Retrieved 2020-03-02.
  15. "Alert App | Real Time Seizure Alerts | Embrace Watch". Empatica. Retrieved 2020-03-02.
  16. "Sunovion taps Empatica for Phase 4 drug trial -- and two other digital health projects targeting epilepsy". MobiHealthNews. 2016-12-05. Retrieved 2020-03-02.
  17. Johnson, Kristina T.; Taylor, Sara; Fedor, Szymon; Jaques, Natasha; Chen, Weixuan; Picard, Rosalind W. (July 2018). "Vomit Comet Physiology: Autonomic Changes in Novice Flyers". 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE. doi:10.1109/embc.2018.8512414. hdl:1721.1/123805. ISBN 978-1-5386-3646-6.
  18. "Mate App | Seizure Diary | Activity and Rest Monitoring". Empatica. Retrieved 2020-03-02.
  19. "Real-time physiological signals | E4 EDA/GSR sensor". Empatica. Retrieved 2020-03-02.
  20. Muoio, Danielle. "This wearable could help combat opioid addiction". Business Insider. Retrieved 2020-03-02.
  21. Russey, Cathy (2019-11-21). "Wearables Can Reliably Assess Engagement, Reveals Empatica Study". Wearable Technologies. Retrieved 2020-03-02.
  22. September 2019, 23rd. "5 Digital Health Care Advances". IoT World Today. Retrieved 2020-03-02.
  23. "Empatica unveils wearable monitor for mission to Mars". Verdict Medical Devices. 2019-11-20. Retrieved 2020-03-02.
  24. Mars, Kelli (2017-11-22). "The Translational Research Institute for Space Health (TRISH)". NASA. Retrieved 2020-03-02.
  25. "Improvement of a convulsive seizure detector relying on accelerometer and electrodermal activity collected continuously by a wristband". Research Gate. Retrieved 2020-06-19.
  26. "Happy with a 20% chance of sadness". Nature. Retrieved 2020-06-19.
  27. "HHS EXPANDS INNOVATION PARTNERSHIPS WITH PRIVATE SECTOR". HealthLeaders. Retrieved 2020-06-19.
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