ERRFI1

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[5][6][7][8][9]

ERRFI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDsOMIM: 608069 MGI: 1921405 HomoloGene: 10344 GeneCards: ERRFI1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.23Start8,004,404 bp[1]
End8,026,309 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54206

74155

Ensembl

ENSG00000116285

ENSMUSG00000028967

UniProt

Q9UJM3

Q99JZ7

RefSeq (mRNA)

NM_018948

NM_133753
NM_001356323

RefSeq (protein)

NP_061821

NP_598514
NP_001343252

Location (UCSC)Chr 1: 8 – 8.03 MbChr 4: 150.85 – 150.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][9]

Interactions

ERRFI1 has been shown to interact with Stratifin[10] and CDC42.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000116285 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028967 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (June 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". The Journal of Biological Chemistry. 275 (23): 17838–47. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.
  6. Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (August 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Research. 17 (16): 6651–67. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
  7. Fiorini M, Ballarò C, Sala G, Falcone G, Alemà S, Segatto O (September 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–9. doi:10.1038/sj.onc.1205823. PMID 12226756.
  8. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alemà S, Benedetti P, Segatto O (October 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Molecular and Cellular Biology. 20 (20): 7735–50. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
  9. "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".
  10. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

Further reading
  • Zhang YW, Vande Woude GF (March 2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507–13. doi:10.4161/cc.6.5.3928. PMID 17351343.
  • Wick M, Bürger C, Funk M, Müller R (August 1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Experimental Cell Research. 219 (2): 527–35. doi:10.1006/excr.1995.1261. PMID 7641805.
  • Hackel PO, Gishizky M, Ullrich A (December 2001). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biological Chemistry. 382 (12): 1649–62. doi:10.1515/BC.2001.200. PMID 11843178.
  • Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S (October 2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Research. 62 (20): 5668–71. PMID 12384522.
  • Saarikoski ST, Rivera SP, Hankinson O (October 2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Letters. 530 (1–3): 186–90. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
  • Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, Alemà S, Alimandi M, Segatto O (July 2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221–34. doi:10.1038/sj.onc.1206516. PMID 12833145.
  • Xu D, Makkinje A, Kyriakis JM (January 2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". The Journal of Biological Chemistry. 280 (4): 2924–33. doi:10.1074/jbc.M408907200. PMID 15556944.
  • Keeton AB, Messina JL (April 2005). "Modulation of Elk-dependent-transcription by Gene33". Journal of Cellular Biochemistry. 94 (6): 1190–8. doi:10.1002/jcb.20370. PMID 15696545.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, Lucini F, Ingvarsson S, Segatto O (June 2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene. 24 (28): 4540–8. doi:10.1038/sj.onc.1208658. PMID 15856022.
  • Ballarò C, Ceccarelli S, Tiveron C, Tatangelo L, Salvatore AM, Segatto O, Alemà S (August 2005). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Reports. 6 (8): 755–61. doi:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071.
  • Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, Cao B, Resau J, Sigler R, Bronson R, Vande Woude GF (January 2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–76. doi:10.1038/sj.onc.1209790. PMID 16819504.
  • Overview of all the structural information available in the PDB for UniProt: Q9UJM3 (ERBB receptor feedback inhibitor 1) at the PDBe-KB.
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