E2F7

E2F7
Identifiers
Aliases	E2F7, E2F transcription factor 7
External IDs	OMIM: 612046 MGI: 1289147 HomoloGene: 18685 GeneCards: E2F7
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	77,065,569 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	110,787,384 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • core promoter binding; • GO:0001106 transcription corepressor activity; • GO:0001948 protein binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • identical protein binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001158 core promoter proximal region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • sequence-specific DNA binding;
Cellular component	• transcription factor complex; • cell nucleus; • nucleoplasm; • nuclear speck; • RNA polymerase II transcription factor complex;
Biological process	• trophoblast giant cell differentiation; • regulation of transcription, DNA-templated; • chorionic trophoblast cell differentiation; • negative regulation of transcription involved in G1/S transition of mitotic cell cycle; • placenta development; • DNA damage response, signal transduction by p53 class mediator; • hepatocyte differentiation; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • negative regulation of G1/S transition of mitotic cell cycle; • cell cycle; • negative regulation of cytokinesis; • positive regulation of DNA endoreduplication; • positive regulation of transcription from RNA polymerase II promoter; • sprouting angiogenesis; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • negative regulation of cell proliferation; • regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	144455
	52679
	ENSG00000165891
	ENSMUSG00000020185
	Q96AV8
	Q6S7F2
	NM_203394
	NM_178609; NM_001358560
	NP_976328
	NP_848724; NP_001345489
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E2F7 is a protein that in humans is encoded by the E2F7 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000165891 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020185 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G (Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278 (43): 42041–9. doi:10.1074/jbc.M308105200. PMID 12893818.
"Entrez Gene: E2F7 E2F transcription factor 7".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Reimer D, Sadr S, Wiedemair A, et al. (2007). "Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients". Clin. Cancer Res. 13 (1): 144–51. doi:10.1158/1078-0432.CCR-06-0780. PMID 17200349.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Logan N, Graham A, Zhao X, et al. (2005). "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7". Oncogene. 24 (31): 5000–4. doi:10.1038/sj.onc.1208703. PMID 15897886.
Logan N, Delavaine L, Graham A, et al. (2004). "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains". Oncogene. 23 (30): 5138–50. doi:10.1038/sj.onc.1207649. PMID 15133492.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Di Stefano L, Jensen MR, Helin K (2004). "E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes". EMBO J. 22 (23): 6289–98. doi:10.1093/emboj/cdg613. PMC 291854. PMID 14633988.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165891 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020185 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12893818-5] Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G (Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278 (43): 42041–9. doi:10.1074/jbc.M308105200. PMID 12893818.

[entrez-6] "Entrez Gene: E2F7 E2F transcription factor 7".

E2F7

References

Further reading