E-box 1 of insulin gene

E1 is a regulatory sequence for the insulin gene.[1]

An important role of E-box in exon 1 is to regulate genes in muscle cells. E-box's promoter regulates whether Insulin-like growth factor I (IGF-I) is expressed. The expression of IGF-I gene is responsible for muscle cell regulation.[2]

References
  1. Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription
  2. McLellan, A. S.; Kealey, T.; Langlands, K. (2006-08-01). "An E box in the exon 1 promoter regulates insulin-like growth factor-I expression in differentiating muscle cells". American Journal of Physiology. Cell Physiology. 291 (2): C300–C307. doi:10.1152/ajpcell.00345.2005. ISSN 0363-6143.


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