Duffy binding proteins
In molecular biology, Duffy binding proteins are found in plasmodia. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa.[1][2]
| Duffy binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of eba-175 region ii (rii) crystallized in the presence of (alpha)2,3-sialyllactose | |||||||||
| Identifiers | |||||||||
| Symbol | Duffy_binding | ||||||||
| Pfam | PF05424 | ||||||||
| Pfam clan | CL0195 | ||||||||
| InterPro | IPR008602 | ||||||||
| |||||||||
| Duffy binding protein N terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DuffyBP_N | ||||||||
| Pfam | PF12377 | ||||||||
| InterPro | IPR021032 | ||||||||
| |||||||||
See also
- Genetic resistance to malaria
- Plasmodium falciparum erythrocyte membrane protein 1
References
- Adams JH, Hudson DE, Torii M, Ward GE, Wellems TE, Aikawa M, Miller LH (October 1990). "The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites". Cell. 63 (1): 141–53. doi:10.1016/0092-8674(90)90295-P. PMID 2170017.
- Babaeekho, L.; Zakeri, S.; Djadid, N. D. (2009). "Genetic mapping of the duffy binding protein (DBP) ligand domain of Plasmodium vivax from unstable malaria region in the Middle East". The American Journal of Tropical Medicine and Hygiene. 80 (1): 112–118. doi:10.4269/ajtmh.2009.80.112. PMID 19141848.
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