DLGAP4

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.[5][6]

DLGAP4
Identifiers
AliasesDLGAP4, DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4, discs large homolog associated protein 4, DLG associated protein 4
External IDsOMIM: 616191 MGI: 2138865 HomoloGene: 8935 GeneCards: DLGAP4
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.23Start36,306,336 bp[1]
End36,528,637 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22839

228836

Ensembl

ENSG00000080845

ENSMUSG00000061689

UniProt

Q9Y2H0

B1AZP2

RefSeq (mRNA)

NM_001042486
NM_014902
NM_183006
NM_001365621

NM_001042487
NM_001042488
NM_001277186
NM_001277187
NM_146128

RefSeq (protein)

NP_001035951
NP_055717
NP_892118
NP_001352550

NP_001035952
NP_001035953
NP_001264115
NP_001264116
NP_666240

Location (UCSC)Chr 20: 36.31 – 36.53 MbChr 2: 156.61 – 156.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000080845 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061689 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y (Jun 1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J Biol Chem. 272 (18): 11943–51. doi:10.1074/jbc.272.18.11943. PMID 9115257.
  6. "Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.