DHX15

DHX15
Identifiers
Aliases	DHX15, DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15
External IDs	OMIM: 603403 MGI: 1099786 HomoloGene: 1040 GeneCards: DHX15
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	24,584,554 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	52,190,514 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• RNA helicase activity; • nucleotide binding; • double-stranded RNA binding; • ATP-dependent RNA helicase activity; • GO:0001948 protein binding; • ATP binding; • GO:0008026 helicase activity; • hydrolase activity; • nucleic acid binding; • RNA binding; • GO:0034459 3'-5' RNA helicase activity;
Cellular component	• U12-type spliceosomal complex; • nucleolus; • U2-type post-mRNA release spliceosomal complex; • cytoplasm; • cell nucleus; • nucleoplasm; • nuclear speck;
Biological process	• mRNA processing; • response to alkaloid; • response to toxic substance; • RNA splicing; • mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	1665
	13204
	ENSG00000109606
	ENSMUSG00000029169
	O43143
	O35286
	NM_001358
	NM_001042620; NM_007839
	NP_001349
	NP_001036085; NP_031865
	Wikidata
View/Edit Human	View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.[5][6]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.[6]

References

GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
"Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349. PMID 12458796.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. doi:10.1128/MCB.14.11.7611. PMC 359297. PMID 7935475.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109606 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029169 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388478-5] Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.

[entrez-6] "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

DHX15

References

Further reading