DEFB104A

Beta-defensin 104 is a protein that in humans is encoded by the DEFB104A gene.[3]

DEFB104A
Identifiers
AliasesDEFB104A, BD-4, DEFB-4, DEFB104, DEFB4, hBD-4, defensin beta 104A
External IDsHomoloGene: 88640 GeneCards: DEFB104A
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p23.1Start7,836,436 bp[1]
End7,841,242 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

140596

n/a

Ensembl

ENSG00000176782
ENSG00000285034

n/a

UniProt

Q8WTQ1

n/a

RefSeq (mRNA)

NM_080389

n/a

RefSeq (protein)

NP_001035792

n/a

Location (UCSC)Chr 8: 7.84 – 7.84 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.[3]

References

Further reading


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