DDX50

DDX50
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E29
Identifiers
Aliases	DDX50, GU2, GUB, RH-II/GuB, mcdrh, DEAD-box helicase 50, DExD-box helicase 50
External IDs	OMIM: 610373 MGI: 2182303 HomoloGene: 56986 GeneCards: DDX50
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	68,946,847 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	62,651,218 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • ATP-dependent RNA helicase activity; • hydrolase activity; • ATP binding; • GO:0008026 helicase activity; • nucleic acid binding; • RNA binding;
Cellular component	• cell membrane; • membrane; • cell nucleus; • nucleolus; • cytoplasm;
Biological process	• RNA secondary structure unwinding;
	Sources:Amigo / QuickGO
Orthologs
	79009
	94213
	ENSG00000107625
	ENSMUSG00000020076
	Q9BQ39
	Q99MJ9
	NM_024045
	NM_053183; NM_001358819; NM_001358820
	NP_076950
	NP_444413; NP_001345748; NP_001345749
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene.[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.[6]

References

GRCh38: Ensembl release 89: ENSG00000107625 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020076 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Valdez BC, Yang H, Hong E, Sequitin AM (Mar 2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.
"Entrez Gene: DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107625 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020076 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11891046-5] Valdez BC, Yang H, Hong E, Sequitin AM (Mar 2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.

[entrez-6] "Entrez Gene: DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50".

DDX50

References

Further reading