DDX3Y

ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.[5][6]

DDX3Y
Identifiers
AliasesDDX3Y, DBY, DEAD-box helicase 3, Y-linked, DEAD-box helicase 3 Y-linked
External IDsOMIM: 400010 MGI: 1349406 HomoloGene: 55839 GeneCards: DDX3Y
Gene location (Human)
Chr.Y chromosome (human)[1]
BandYq11.221Start12,904,108 bp[1]
End12,920,478 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8653

26900

Ensembl

ENSG00000067048

ENSMUSG00000069045

UniProt

O15523

Q62095

RefSeq (mRNA)

NM_001122665
NM_001302552
NM_004660
NM_001324195

NM_012008

RefSeq (protein)

NP_001116137
NP_001289481
NP_001311124
NP_004651

NP_036138

Location (UCSC)Chr Y: 12.9 – 12.92 MbChr Y: 1.26 – 1.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X). The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternative splicing of this gene generates 2 transcripts, which differ only in the length of the 3' UTR.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000067048 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069045 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
  6. "Entrez Gene: DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked".

Further reading


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