Corynebacterium pseudotuberculosis

Corynebacterium pseudotuberculosis is a common cause of the bacterial livestock disease caseous lymphadenitis which occurs in sheep, goats, cattle, buffalo and horses.[1] C. pseudotuberculosis is a gram-positive, oxygen requiring (facultative aerobic) bacteria that lives in soil and is transmitted via flies. This bacteria exhibits limited susceptibility to current antibiotic treatments which makes treating infections caused by the bacteria difficult.[2]

Corynebacterium pseudotuberculosis
Scientific classification
Domain: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species:
C. pseudotuberculosis
Binomial name
Corynebacterium pseudotuberculosis

The bacteria exhibits a capacity for jumping between different host species (host switching). The ability to jump between hosts has been linked to the bacteria's rapid evolution and genomic flexibility.[3][4] Vaccines for the bacterial strains that infect sheep are currently commercially available and use of the vaccine is reported to decrease disease severity;[5] however, vaccines responsible for infecting other strains are still not widely available.

References
  1. "Corynebacterium pseudotuberculosis Infection of Horses and Cattle - Circulatory System". Merck Veterinary Manual. Retrieved 2020-05-27.
  2. Gao, Huafeng; Ma, Yuxing; Shao, Qingyong; Hong, Qionghua; Zheng, Guoying; Li, Zhiming (2018-03-15). "Genome sequence of Corynebacterium pseudotuberculosis strain KM01, isolated from the abscess of a goat in Kunming, China". Genome Announcements. 6 (11). doi:10.1128/genomeA.00013-18. ISSN 2169-8287. PMC 5854783. PMID 29545288.
  3. Viana, Marcus Vinicius Canário; Sahm, Arne; Góes Neto, Aristóteles; Figueiredo, Henrique Cesar Pereira; Wattam, Alice Rebecca; Azevedo, Vasco (2018-11-12). "Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis". PLoS ONE. 13 (11). doi:10.1371/journal.pone.0207304. ISSN 1932-6203. PMC 6231662. PMID 30419061.
  4. Baraúna, Rafael A.; Ramos, Rommel T. J.; Veras, Adonney A. O.; Pinheiro, Kenny C.; Benevides, Leandro J.; Viana, Marcus V. C.; Guimarães, Luís C.; Edman, Judy M.; Spier, Sharon J.; Azevedo, Vasco; Silva, Artur (2017-01-26). "Assessing the Genotypic Differences between Strains of Corynebacterium pseudotuberculosis biovar equi through Comparative Genomics". PLoS ONE. 12 (1). doi:10.1371/journal.pone.0170676. ISSN 1932-6203. PMC 5268413. PMID 28125655.
  5. Piontkowski, M.D.; Shivvers, D.W. (1998-06-01). "Evaluation of a commercially available vaccine against Corynebacterium Pseudotuberculosis for use in sheep". Journal of the American Veterinary Medical Association. PMID 9621886.
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