Conophylline

Conophylline
Identifiers
	IUPAC name dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate;
CAS Number	142741-24-0;
PubChem CID	9853848;
ChemSpider	23339619;
ChEMBL	ChEMBL506768;
Chemical and physical data
Formula	C44H50N4O10
Molar mass	794.902 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC12CC(=C3C4(C1N(CC4)C5C(C2O)OC6=CC7=C(C=C56)C89CCN1C8C(CC(=C9N7)C(=O)OC)(C2C(C1)O2)CC)C1=CC(=C(C(=C1N3)OC)OC)O)C(=O)OC;
	InChI InChI=1S/C44H50N4O10/c1-7-41-16-20(37(51)55-5)34-44(23-14-25(49)30(53-3)31(54-4)28(23)46-34)10-12-48(40(41)44)29-19-13-22-24(15-26(19)57-32(29)35(41)50)45-33-21(38(52)56-6)17-42(8-2)36-27(58-36)18-47-11-9-43(22,33)39(42)47/h13-15,27,29,32,35-36,39-40,45-46,49-50H,7-12,16-18H2,1-6H3; Key:QZRIMAMDGWAHPQ-UHFFFAOYSA-N;

Conophylline is a naturally occurring substance.It has anti-tumorogenic effects.[1]

Uses

Medical

It increased number of insulin-positive cells. It also increased insulin production in carcinogenic cells. It lowers blood glucose levels as well as inhibits TNF-alpha induced activations. It may prove useful for diabetic patients.

References

http://medind.nic.in/iby/t08/i4/ibyt08i4p317.pdf

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[1] ttp://medind.nic.in/iby/t08/i4/ibyt08i4p317.pdf