Comprehensive Antibiotic Resistance Database

The Comprehensive Antibiotic Resistance Database (CARD) is a biological database that collects and organizes reference information on antimicrobial resistance genes, proteins and phenotypes.[1] [2] The database covers all types of drug classes and resistance mechanisms and structures its data based on an ontology. The CARD database was one of the first resources that covered antimicrobial resistance genes.[3] The resource is updated monthly [4] and provides tools to allow users to find potential antibiotic resistance genes in newly-sequenced genomes. Information that is added to CARD includes: antibiotic resistance genes, antibiotic ontology and antibiotic resistance mechanism of action. Currently as of June 2020, CARD contains 4463 Ontology Terms, 2984 Reference Sequences, 1334 SNPs, 2685 Publications, 3030 AMR Detection Models. Resistome predictions: 88 pathogens, 9560 chromosomes, 21362 plasmids, 102181 WGS assemblies, 222011 alleles [4].

The Comprehensive Antibiotic Resistance Database
Content
DescriptionThe Comprehensive Antibiotic Resistance Database provides data, models, and algorithms relating to the molecular basis of antimicrobial resistance.
Data types
captured		Antimicrobial resistance genes and phenotypes
OrganismsBacteria
Contact
Research centerMcMaster University
Primary citationPMID 27789705
Access
Websitecard.mcmaster.ca
Download URLDownload
Miscellaneous
Bookmarkable
entities		yes

See also

References
  1. Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A; et al. (2020). "CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database". Nucleic Acids Res. 48 (D1): D517–D525. doi:10.1093/nar/gkz935. PMC 7145624. PMID 31665441.CS1 maint: multiple names: authors list (link)
  2. Jia, B; Raphenya, AR; Alcock, B; Waglechner, N; Guo, P; Tsang, KK; Lago, BA; Dave, BM; Pereira, S; Sharma, AN; Doshi, S; Courtot, M; Lo, R; Williams, LE; Frye, JG; Elsayegh, T; Sardar, D; Westman, EL; Pawlowski, AC; Johnson, TA; Brinkman, FS; Wright, GD; McArthur, AG (4 January 2017). "CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database". Nucleic Acids Research. 45 (D1): D566–D573. doi:10.1093/nar/gkw1004. PMC 5210516. PMID 27789705.
  3. McArthur, AG; Waglechner, N; Nizam, F; Yan, A; Azad, MA; Baylay, AJ; Bhullar, K; Canova, MJ; De Pascale, G; Ejim, L; Kalan, L; King, AM; Koteva, K; Morar, M; Mulvey, MR; O'Brien, JS; Pawlowski, AC; Piddock, LJ; Spanogiannopoulos, P; Sutherland, AD; Tang, I; Taylor, PL; Thaker, M; Wang, W; Yan, M; Yu, T; Wright, GD (July 2013). "The comprehensive antibiotic resistance database". Antimicrobial Agents and Chemotherapy. 57 (7): 3348–57. doi:10.1128/AAC.00419-13. PMC 3697360. PMID 23650175.
  4. "CARD website". Retrieved 5 June 2020.
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