Collaborative Drug Discovery

Collaborative Drug Discovery (CDD) is a software company founded in 2004 as a spin-out of Eli Lilly by Barry Bunin, PhD. CDD offers a web-based database solution for managing drug discovery data, primarily around small molecules and associated bio-assay data.

Collaborative Drug Discovery, Inc.
Private
IndustryLife sciences, informatics
Founded2004 (2004)
HeadquartersBurlingame, California
ProductsCDD Vault,
CDD Collaborate,
CDD Public
Websitewww.collaborativedrug.com

Products

CDD Vault[1][2] is a complete informatics web platform by Collaborative Drug Discovery. It contains several modules for collaborative project teams to manage, analyze, and share both private & public data. It is used by biotech companies, CROs, academic labs, research hospitals, agrochemical and consumer goods companies. CDD Vault is a modern web application for chemical registration, assay data management, and SAR analysis. It is designed to be simple to use and extremely secure.

CDD Vault modules Type Description
Activity & Registration[3] Chemical registration system Web application within CDD Vault for chemical registration, assay data management, and SAR analysis.
Visualization[4] Scientific visualization Web application within CDD Vault allowing plotting and analysis of large data sets to find interesting patterns, activity hotspots, and outliers.
ELN[5] Electronic lab notebook Web application within CDD Vault that integrates a full analysis and visualization environment with chemical and biological assay data repositories.
Inventory[6] Inventory management software Web application integrated within CDD Vault for tracking the supply and location of compounds and reagents.
CDD Public[7] Chemical database Free database also integrated within CDD Vault for fostering open collaboration containing over 3 million molecules accessible to everyone in the drug discovery community.

Collaborations

The capability for inter-group collaboration attracted attention from the Bill & Melinda Gates Foundation, who in 2008 awarded CDD with a two million dollar grant being used to support researchers combating tuberculosis.[8]

In 2010, GlaxoSmithKline released 13,471 molecules screened for activity against malaria to the public. These molecules and their associated screening data are available via CDD Public, as well in as the National Library of Medicine's PubChem and the European Bioinformatics Institute's ChEMBL database.[9] This data has served as the basis for several cheminformatics analyses.[10][11][12]

In February 2011 CDD began participating in the collaborative MM4TB project led by Stewart Cole[13] and including participants from AstraZeneca and Sanofi Aventis.[14]

See also

References
  1. http://tsdr.uspto.gov/documentviewer?caseId=sn77791158&docId=ORC20101207004753#docIndex=6&page=1
  2. https://www.collaborativedrug.com/benefits/
  3. https://www.collaborativedrug.com/benefits/activity-registration/ 
  4. https://www.collaborativedrug.com/benefits/visualization/
  5. https://www.collaborativedrug.com/benefits/eln/
  6. https://www.collaborativedrug.com/benefits/inventory/
  7. https://www.collaborativedrug.com/public-access/
  8. Collaborative Drug Discovery Receives Grant to Support the Development of a Database to Accelerate Discovery of New Therapies Against Tuberculosis
  9. New research identifies promising leads to follow in search for medicines to fight malaria Archived 2010-06-01 at the Wayback Machine
  10. Sean Ekins and Antony John Williams, When Pharmaceutical Companies Publish Large Datasets: An Abundance of riches or fool’s gold? Drug Disc Today, 15; 812-815, 2010
  11. Ekins S and Williams AJ, Meta-analysis of molecular property patterns and filtering of public datasets of antimalarial “hits” and drugs, MedChemComm, 1: 325-330, 2010
  12. Ekins S, Kaneko T, Lipinski CA, Bradford J, Dole K, Spektor A, Gregory K, Blondeau D, Ernst S, Yang J, Goncharoff N, Hohman M and Bunin BA, Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis, Mol Biosyst, 6: 2316-2324, 2010
  13. http://cole-lab.epfl.ch/
  14. http://mm4tb.org/
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