Clodagh O'Shea

Clodagh C. O'Shea is a professor of molecular and cell biology and current Wicklow Chair at the Salk Institute for Biological Sciences and a scholar at the Howard Hughes Medical Institute.[1]

Clodagh O'Shea
NationalityIrish
Alma materUniversity College Cork, Imperial College London, UCSF Comprehensive Cancer Center
Known forVirally targeting cancer cells
AwardsAllen Distinguished Investigator Award, Howard Hughes Medical Institute Faculty Scholar, W. M. Keck Medical Research Program Award, Rose Hills Fellow, Science/NSF International Science & Visualization Challenge, People's Choice, Anna Fuller Award for Cancer Research, Kavli Frontiers Fellow, National Academy of Sciences
Scientific career
FieldsCancer Biology
InstitutionsSalk Institute for Biological Studies

Education

O'Shea has a BS in biochemistry and microbiology from University College Cork, Ireland and a PhD from Imperial College London. She was a Postdoctoral Fellow at the UCSF Comprehensive Cancer Center, San Francisco, United States.[1]

Selected publications

  • O'Shea, Clodagh C.; Choi, Serah; McCormick, Frank; Stokoe, David (2 May 2005). "Adenovirus Overrides Cellular Checkpoints for Protein Translation". Cell Cycle. 4 (7): 883–888. doi:10.4161/cc.4.7.1791. PMID 15970698.
  • Ringshausen, Ingo; O'Shea, Clodagh C.; Finch, Andrew J.; Swigart, Lamorna Brown; Evan, Gerard I. (December 2006). "Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo". Cancer Cell. 10 (6): 501–514. doi:10.1016/j.ccr.2006.10.010. PMID 17157790.
  • Heimbucher, Thomas; Liu, Zheng; Bossard, Carine; McCloskey, Richard; Carrano, Andrea C.; Riedel, Christian G.; Tanasa, Bogdan; Klammt, Christian; Fonslow, Bryan R.; Riera, Celine E.; Lillemeier, Bjorn F. (July 2015). "The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity". Cell Metabolism. 22 (1): 151–163. doi:10.1016/j.cmet.2015.06.002. PMC 4502596. PMID 26154057.
  • Shah, Govind A.; O'Shea, Clodagh C. (August 2015). "Viral and Cellular Genomes Activate Distinct DNA Damage Responses". Cell. 162 (5): 987–1002. doi:10.1016/j.cell.2015.07.058. PMC 4681434. PMID 26317467.
  • Higginbotham, Jennifer M.; O'Shea, Clodagh C. (15 October 2015). Imperiale, M. J. (ed.). "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains". Journal of Virology. 89 (20): 10260–10272. doi:10.1128/JVI.01091-15. ISSN 0022-538X. PMC 4580165. PMID 26223632.
  • Ou, Horng D.; Deerinck, Thomas J.; Bushong, Eric; Ellisman, Mark H.; O'Shea, Clodagh C. (November 2015). "Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy". Methods. 90: 39–48. doi:10.1016/j.ymeth.2015.06.002. PMC 4655137. PMID 26066760.
  • Tufail, Yusuf; Cook, Daniela; Fourgeaud, Lawrence; Powers, Colin J.; Merten, Katharina; Clark, Charles L.; Hoffman, Elizabeth; Ngo, Alexander; Sekiguchi, Kohei J.; O'Shea, Clodagh C.; Lemke, Greg (February 2017). "Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia". Neuron. 93 (3): 574–586.e8. doi:10.1016/j.neuron.2016.12.021. PMC 5600182. PMID 28111081.
  • Ou, Horng D.; Phan, Sébastien; Deerinck, Thomas J.; Thor, Andrea; Ellisman, Mark H.; O'Shea, Clodagh C. (28 July 2017). "ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells". Science. 357 (6349): eaag0025. doi:10.1126/science.aag0025. ISSN 0036-8075. PMC 5646685. PMID 28751582.
  • Dekker, Job; Belmont, Andrew S.; Guttman, Mitchell; Leshyk, Victor O.; Lis, John T.; Lomvardas, Stavros; Mirny, Leonid A.; O'Shea, Clodagh C.; Park, Peter J.; Ren, Bing; Politz, Joan C. Ritland; Shendure, Jay; Zhong, Sheng (14 September 2017). "The 4D nucleome project". Nature. 549 (7671): 219–226. doi:10.1038/nature23884. PMC 5617335. PMID 28905911.

Awards[2]

  • 2018 Paul G. Allen Frontiers Group's Allen Distinguished Investigator[3]
  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigators Award[4]
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar

References

  1. "Clodagh O'Shea". Salk Institute. Retrieved March 14, 2020.
  2. "Clodagh O'Shea". Salk Institute for Biological Studies. Retrieved 2020-03-25.
  3. "Assembling DNA into cromatin". Salk News.
  4. "Awarded Scientists". Arnold and Mabel Beckman Foundation. Retrieved 2020-02-26.

Further reading


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