Chromatin target of prmt1

CHTOP
Identifiers
Aliases	CHTOP, C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704, chromatin target of PRMT1, C10orf77
External IDs	OMIM: 614206 HomoloGene: 134556 GeneCards: CHTOP
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	153,646,306 bp[1]
Gene ontology
Molecular function	• methyl-CpG binding; • GO:0001948 protein binding; • RNA binding;
Cellular component	• nuclear speck; • nucleolus; • transcription export complex; • cell nucleus; • nucleoplasm; • cytoplasmic ribonucleoprotein granule;
Biological process	• mRNA transport; • regulation of transcription, DNA-templated; • positive regulation of ATPase activity; • positive regulation of helicase activity; • positive regulation of histone methylation; • transcription, DNA-templated; • positive regulation of cell proliferation; • RNA export from nucleus; • termination of RNA polymerase II transcription; • mRNA export from nucleus; • mRNA 3'-end processing; • transport;
	Sources:Amigo / QuickGO
Orthologs
	26097
	n/a
	ENSG00000160679
	n/a
	Q9Y3Y2
	n/a
	NM_001206612; NM_001244664; NM_015607; NM_001317077
	n/a
	NP_001193541; NP_001231593; NP_001304006; NP_056422
	n/a
	Wikidata
View/Edit Human

Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene.[3]

Function

This gene encodes a small nuclear protein that is characterized by a arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000160679 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Chromatin target of PRMT1".

Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation". The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). "Chtop is a component of the dynamic TREX mRNA export complex". The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells". PLOS One. 8 (6): e67676. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases". Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160679 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Chromatin target of PRMT1".

Chromatin target of prmt1

Function

References

Further reading