Chlorozotocin

Chlorozotocin
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-{[(2-Chloroethyl)(nitroso)carbamoyl]amino}-2-deoxy-D-glucose;
CAS Number	54749-90-5 ;
PubChem CID	451706;
ChemSpider	397854 ;
UNII	3053LTY75Z;
KEGG	C19170 ;
ChEMBL	ChEMBL2094020 ;
CompTox Dashboard (EPA)	DTXSID9020320 ;
Chemical and physical data
Formula	C9H16ClN3O7
Molar mass	313.69 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCCN(N=O)C(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO;
	InChI InChI=1S/C9H16ClN3O7/c10-1-2-13(12-20)9(19)11-5(3-14)7(17)8(18)6(16)4-15/h3,5-8,15-18H,1-2,4H2,(H,11,19)/t5-,6+,7+,8+/m0/s1 ; Key:MKQWTWSXVILIKJ-LXGUWJNJSA-N ;
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Chlorozotocin is a nitrosourea. It is used for cancer therapy.

The International Agency for Research on Cancer concluded it was "probably carcinogenic" in 1990[1]

IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans, No. 50.

IARC Working Group on the Evaluation of Carcinogenic Risk to Humans.

Lyon (FR): International Agency for Research on Cancer; 1990.

It is an analogue of streptozotocin.[2]

References

Humans, IARC Working Group on the Evaluation of Carcinogenic Risk to (1990). SUMMARY OF FINAL EVALUATIONS. International Agency for Research on Cancer.
Wolfe, M. Michael (2006). Therapy of digestive disorders. Elsevier Health Sciences. p. 477. ISBN 978-1-4160-0317-5.

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