Calumenin

CALU
Identifiers
Aliases	CALU, calumenin
External IDs	OMIM: 603420 MGI: 1097158 HomoloGene: 936 GeneCards: CALU
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	128,773,400 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	29,377,110 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• calcium ion binding; • metal ion binding; • GO:0001948 protein binding;
Cellular component	• Golgi apparatus; • endoplasmic reticulum membrane; • membrane; • melanosome; • sarcoplasmic reticulum; • extracellular region; • endoplasmic reticulum; • sarcoplasmic reticulum lumen; • endoplasmic reticulum lumen;
Biological process	• post-translational modification; • cellular protein metabolic process; • biological process;
	Sources:Amigo / QuickGO
Orthologs
	813
	12321
	ENSG00000128595
	ENSMUSG00000029767
	O43852
	O35887
NM_001130674; NM_001199671; NM_001199672; NM_001199673; NM_001199674;
	NM_001219
	NM_001285412; NM_007594; NM_184053
	NP_001124146; NP_001186600; NP_001186601; NP_001186602; NP_001210
	NP_001272341; NP_031620; NP_908942
	Wikidata
View/Edit Human	View/Edit Mouse

Calumenin is a protein that in humans is encoded by the CALU gene.[5][6]

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.[6]

References

GRCh38: Ensembl release 89: ENSG00000128595 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029767 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. doi:10.1006/geno.1998.5245. PMID 9598325.
"Entrez Gene: CALU calumenin".

External links

Human CALU genome location and CALU gene details page in the UCSC Genome Browser.

Yabe D, Nakamura T, Kanazawa N, et al. (1997). "Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF". J. Biol. Chem. 272 (29): 18232–9. doi:10.1074/jbc.272.29.18232. PMID 9218460.
Vorum H, Liu X, Madsen P, et al. (1998). "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity". Biochim. Biophys. Acta. 1386 (1): 121–31. doi:10.1016/s0167-4838(98)00089-2. PMID 9675259.
Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2". FEBS Lett. 445 (2–3): 440–4. doi:10.1016/S0014-5793(99)00177-5. PMID 10094503.
Vorum H, Hager H, Christensen BM, et al. (1999). "Human calumenin localizes to the secretory pathway and is secreted to the medium". Exp. Cell Res. 248 (2): 473–81. doi:10.1006/excr.1999.4431. PMID 10222138.
Vorum H, Jacobsen C, Honoré B (2000). "Calumenin interacts with serum amyloid P component". FEBS Lett. 465 (2–3): 129–34. doi:10.1016/S0014-5793(99)01734-2. PMID 10631319.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128595 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029767 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598325-5] Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. doi:10.1006/geno.1998.5245. PMID 9598325.

[entrez-6] "Entrez Gene: CALU calumenin".

Calumenin

References

External links

Further reading