CTDSP2

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.[5][6][7]

CTDSP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTDSP2, OS4, PSR2, SCP2, CTD small phosphatase 2
External IDsOMIM: 608711 MGI: 1098748 HomoloGene: 128791 GeneCards: CTDSP2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q14.1Start57,819,927 bp[1]
End57,846,729 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10106

52468

Ensembl

ENSG00000175215

ENSMUSG00000078429

UniProt

O14595

Q8BX07

RefSeq (mRNA)

NM_005730

NM_001113470
NM_146012

RefSeq (protein)

NP_005721
NP_005721.3

NP_001106941
NP_666124

Location (UCSC)Chr 12: 57.82 – 57.85 MbChr 10: 126.98 – 127 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

CTDSP2 has been shown to interact with SNAI1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000175215 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000078429 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Su YA, Lee MM, Hutter CM, Meltzer PS (September 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene. 15 (11): 1289–94. doi:10.1038/sj.onc.1201294. PMID 9315096.
  6. Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
  7. "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
  8. Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading


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