CORO2A

Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[5]

CORO2A
Identifiers
AliasesCORO2A, CLIPINB, IR10, WDR2, coronin 2A
External IDsOMIM: 602159 MGI: 1345966 HomoloGene: 2546 GeneCards: CORO2A
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.33Start98,120,975 bp[1]
End98,192,637 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7464

107684

Ensembl

ENSG00000106789

ENSMUSG00000028337

UniProt

Q92828

Q8C0P5

RefSeq (mRNA)

NM_003389
NM_052820

NM_001164804
NM_178893

RefSeq (protein)

NP_003380
NP_438171

NP_001158276
NP_849224

Location (UCSC)Chr 9: 98.12 – 98.19 MbChr 4: 46.54 – 46.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000106789 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028337 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.

Further reading

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