CLEC2D

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.[3]

CLEC2D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4QKG, 4QKH, 4QKI, 4QKJ, 4WCO
Identifiers
Aliases	CLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs	OMIM: 605659 HomoloGene: 137257 GeneCards: CLEC2D
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 9,664,969 bp[1] End 9,699,553 bp[1]
Gene ontology Molecular function • transmembrane signaling receptor activity • carbohydrate binding • GO:0001948 protein binding Cellular component • cell membrane • membrane • integral component of membrane • endoplasmic reticulum • integral component of plasma membrane • cell surface Biological process • regulation of immune response • cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29121	n/a
Ensembl	ENSG00000069493	n/a
UniProt	Q9UHP7	n/a
RefSeq (mRNA)	NM_001004419 NM_001004420 NM_001197317 NM_001197318 NM_001197319 NM_013269	n/a
RefSeq (protein)	NP_001004419 NP_001184246 NP_001184247 NP_001184248 NP_037401	n/a
Location (UCSC)	Chr 12: 9.66 – 9.7 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.