CIZ1

CIZ1
Identifiers
Aliases	CIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDs	OMIM: 611420 MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	128,204,383 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	32,380,970 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Orthologs
	25792
	68379
	ENSG00000148337
	ENSMUSG00000039205
	Q9ULV3
	n/a
NM_001131015; NM_001131016; NM_001131017; NM_001131018; NM_001257975;
	NM_001257976; NM_012127
	NM_001252534; NM_001252536; NM_001252537; NM_001252538; NM_028412
NP_001124487; NP_001124488; NP_001124489; NP_001124490; NP_001244904;
	NP_001244905; NP_036259
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[5][6]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[7]

Interactions

CIZ1 has been shown to interact with P21.[5]

References

GRCh38: Ensembl release 89: ENSG00000148337 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039205 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (Dec 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochem Biophys Res Commun. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
"Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D (October 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proc. Natl. Acad. Sci. U.S.A. 109 (45): E3128–35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.

External links

Human CIZ1 genome location and CIZ1 gene details page in the UCSC Genome Browser.

Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". FEBS J. 275 (2): 332–40. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865.
Rahman FA, Ainscough JF, Copeland N, Coverley D (2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Hum. Mutat. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423.
den Hollander P, Rayala SK, Coverley D, Kumar R (2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Res. 66 (22): 11021–9. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Coverley D, Marr J, Ainscough J (2005). "Ciz1 promotes mammalian DNA replication". J. Cell Sci. 118 (Pt 1): 101–12. doi:10.1242/jcs.01599. PMID 15585571.
Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". J. Biomed. Sci. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700.
Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Hum. Mol. Genet. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148337 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039205 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10529385-5] Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (Dec 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochem Biophys Res Commun. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.

[entrez-6] "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".

[pmid23074256-7] Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D (October 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proc. Natl. Acad. Sci. U.S.A. 109 (45): E3128–35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.