CIAO1

Probable cytosolic iron-sulfur protein assembly protein CIAO1 is a protein that in humans is encoded by the CIAO1 gene.[5][6][7] CIAO1 forms a complex with FAM96B, MMS19, the co-chaperone HSC20 and the scaffold protein ISCU in order to assist iron-sulfur cluster incorporation into cytoplasmic and nuclear iron-sulfur proteins.[8][9]

CIAO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCIAO1, CIA1, WDR39, cytosolic iron-sulfur assembly component 1
External IDsOMIM: 604333 MGI: 1346998 HomoloGene: 55850 GeneCards: CIAO1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q11.2Start96,266,159 bp[1]
End96,274,173 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9391

26371

Ensembl

ENSG00000144021

ENSMUSG00000003662

UniProt

O76071

Q99KN2

RefSeq (mRNA)

NM_004804

NM_025296

RefSeq (protein)

NP_004795

NP_079572

Location (UCSC)Chr 2: 96.27 – 96.27 MbChr 2: 127.24 – 127.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References
  1. GRCh38: Ensembl release 89: ENSG00000144021 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003662 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y (May 1998). "Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1". The Journal of Biological Chemistry. 273 (18): 10880–7. doi:10.1074/jbc.273.18.10880. PMID 9556563.
  6. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (September 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  7. "Entrez Gene: CIAO1 cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)".
  8. Gari K, León Ortiz AM, Borel V, Flynn H, Skehel JM, Boulton SJ (July 2012). "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism". Science. 337 (6091): 243–5. doi:10.1126/science.1219664. PMID 22678361.
  9. Kim KS, Maio N, Singh A, Rouault TA (March 2018). "Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients". Human Molecular Genetics. 27 (5): 837–852. doi:10.1093/hmg/ddy004. PMC 6075588. PMID 29309586.

Further reading
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (November 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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