CHMP4B

CHMP4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C3Q, 3UM3, 4ABM
Identifiers
Aliases	CHMP4B, C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4, charged multivesicular body protein 4B
External IDs	OMIM: 610897 MGI: 1922858 HomoloGene: 57102 GeneCards: CHMP4B
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	33,854,366 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	154,694,785 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • GO:0001948 protein binding; • identical protein binding; • cadherin binding;
Cellular component	• cytoplasm; • ESCRT III complex; • cytosol; • endosome; • membrane; • late endosome membrane; • cytoplasmic side of plasma membrane; • membrane coat; • extracellular exosome; • vesicle; • midbody; • nuclear envelope; • cell nucleus;
Biological process	• negative regulation of autophagosome assembly; • regulation of centrosome duplication; • viral life cycle; • nucleus organization; • maintenance of lens transparency; • multivesicular body assembly; • negative regulation of cell death; • regulation of mitotic spindle assembly; • autophagy; • endosomal transport; • posttranslational protein targeting to endoplasmic reticulum membrane; • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; • protein transport; • cell separation after cytokinesis; • mitotic metaphase plate congression; • protein homooligomerization; • vacuolar transport; • negative regulation of neuron death; • nuclear envelope reassembly; • exit from mitosis; • mitotic cytokinesis; • regulation of autophagy; • membrane fission; • macroautophagy; • transport; • viral budding via host ESCRT complex; • midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	128866
	75608
	ENSG00000101421
	ENSMUSG00000038467
	Q9H444
	Q9D8B3
	NM_176812
	NM_029362
	NP_789782
	NP_083638
	Wikidata
View/Edit Human	View/Edit Mouse

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000101421 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038467 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
"Entrez Gene: CHMP4B chromatin modifying protein 4B".

External links

Human CHMP4A genome location and CHMP4A gene details page in the UCSC Genome Browser.
Human CHMP4B genome location and CHMP4B gene details page in the UCSC Genome Browser.

Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh K, Shibata H, Suzuki H, et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
Sharma M, Pampinella F, Nemes C, et al. (2004). "Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes". J. Cell Biol. 164 (6): 923–33. doi:10.1083/jcb.200312018. PMC 2172283. PMID 15007060.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yorikawa C, Shibata H, Waguri S, et al. (2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem. J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Usami Y, Popov S, Göttlinger HG (2007). "Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site". J. Virol. 81 (12): 6614–22. doi:10.1128/JVI.00314-07. PMC 1900090. PMID 17428861.
Shiels A, Bennett TM, Knopf HL, et al. (2007). "CHMP4B, a Novel Gene for Autosomal Dominant Cataracts Linked to Chromosome 20q". Am. J. Hum. Genet. 81 (3): 596–606. doi:10.1086/519980. PMC 1950844. PMID 17701905.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101421 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038467 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14678797-5] Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.

[entrez-6] "Entrez Gene: CHMP4B chromatin modifying protein 4B".

CHMP4B

References

External links

Further reading