CHMP4A

CHMP4A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3C3O
Identifiers
Aliases	CHMP4A, C14orf123, CHMP4, CHMP4B, HSPC134, SHAX2, SNF7, SNF7-1, VPS32-1, VPS32A, charged multivesicular body protein 4A
External IDs	OMIM: 610051 HomoloGene: 69160 GeneCards: CHMP4A
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	24,213,869 bp[1]
Gene ontology
Molecular function	• protein homodimerization activity; • ATPase binding; • GO:0001948 protein binding; • identical protein binding; • lipid binding;
Cellular component	• cytoplasm; • ESCRT III complex; • cytosol; • endosome; • membrane; • late endosome membrane; • cell membrane; • midbody; • cytoplasmic side of plasma membrane; • membrane coat; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • cell nucleus;
Biological process	• negative regulation of autophagosome assembly; • protein polymerization; • viral life cycle; • nucleus organization; • membrane invagination; • multivesicular body assembly; • plasma membrane tubulation; • endosomal transport; • posttranslational protein targeting to endoplasmic reticulum membrane; • vesicle budding from membrane; • protein transport; • cell separation after cytokinesis; • mitotic metaphase plate congression; • protein homooligomerization; • vacuolar transport; • negative regulation of neuron death; • macroautophagy; • viral budding via host ESCRT complex; • midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	29082
	n/a
	ENSG00000254505; ENSG00000285302
	n/a
	Q9BY43
	n/a
	NM_014169
	n/a
	NP_054888
	n/a
	Wikidata
View/Edit Human

Charged multivesicular body protein 4a is a protein that in humans is encoded by the CHMP4A gene.[3]

References

ENSG00000285302 GRCh38: Ensembl release 89: ENSG00000254505, ENSG00000285302 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CHMP4A chromatin modifying protein 4A".

External links

Human CHMP4A genome location and CHMP4A gene details page in the UCSC Genome Browser.
Human CHMP4B genome location and CHMP4B gene details page in the UCSC Genome Browser.

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh K, Shibata H, Suzuki H, et al. (2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J. Biol. Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
Katoh K, Shibata H, Hatta K, Maki M (2004). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch. Biochem. Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lin Y, Kimpler LA, Naismith TV, et al. (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1". J. Biol. Chem. 280 (13): 12799–809. doi:10.1074/jbc.M413968200. PMID 15632132.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Fisher RD, Chung HY, Zhai Q, et al. (2007). "Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding". Cell. 128 (5): 841–52. doi:10.1016/j.cell.2007.01.035. PMID 17350572.
Shim S, Kimpler LA, Hanson PI (2007). "Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain". Traffic. 8 (8): 1068–79. doi:10.1111/j.1600-0854.2007.00584.x. PMID 17547705.

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[refGRCh38Ensembl-1] ENSG00000285302 GRCh38: Ensembl release 89: ENSG00000254505, ENSG00000285302 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CHMP4A chromatin modifying protein 4A".

CHMP4A

References

External links

Further reading