CDK5RAP3

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.[5][6]

CDK5RAP3
Identifiers
AliasesCDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3
External IDsOMIM: 608202 MGI: 1933126 HomoloGene: 12718 GeneCards: CDK5RAP3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start47,967,810 bp[1]
End47,981,781 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80279

80280

Ensembl

ENSG00000108465

ENSMUSG00000018669

UniProt

Q96JB5

Q99LM2

RefSeq (mRNA)

NM_030248
NM_001308183
NM_001363255
NM_001363256

RefSeq (protein)

NP_001265126
NP_001265127
NP_001265145
NP_001265146
NP_788276

NP_001295112
NP_084524
NP_001350184
NP_001350185

Location (UCSC)Chr 17: 47.97 – 47.98 MbChr 11: 96.91 – 96.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000108465 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018669 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
  6. "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".

Further reading


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