CDK5RAP1

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.[5][6][7][8]

CDK5RAP1
Identifiers
AliasesCDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1
External IDsOMIM: 608200 MGI: 1914221 HomoloGene: 9502 GeneCards: CDK5RAP1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.21Start33,358,839 bp[1]
End33,401,561 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51654

66971

Ensembl

ENSG00000101391

ENSMUSG00000027487

UniProt

Q96SZ6

Q8BTW8

RefSeq (mRNA)

NM_025876

RefSeq (protein)

NP_080152

Location (UCSC)Chr 20: 33.36 – 33.4 MbChr 2: 154.34 – 154.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000101391 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027487 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
  6. Ching YP, Pang AS, Lam WH, Qi RZ, Wang JH (Apr 2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J Biol Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
  7. Zou X, Ji C, Jin F, Liu J, Wu M, Zheng H, Wang Y, Li X, Xu J, Gu S, Xie Y, Mao Y (Aug 2004). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1". Genes Genet Syst. 79 (3): 177–82. doi:10.1266/ggs.79.177. PMID 15329498.
  8. "Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1".

Further reading


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