Bryan J. Traynor

Bryan J. Traynor (born August 12, 1969) is a neurologist and geneticist. He is a senior investigator at the National Institute on Aging and adjunct faculty at Johns Hopkins University.[1] Traynor studies the genetics of human neurological conditions such as amyotrophic lateral sclerosis, frontotemporal dementia, and myasthenia gravis. He led the international consortium that identified pathogenic repeat expansions in the C9orf72[2] gene as a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Traynor also led efforts that identified Mendelian genes responsible for familial amyotrophic lateral sclerosis and dementias including VCP, MATR3, and KIF5A,[3][4] and he identified the CTLA4 locus as a potentially druggable target in patients diagnosed with myasthenia gravis.[5]

Bryan J. Traynor
Born (1969-08-12) August 12, 1969
Dublin, Ireland
CitizenshipIreland, United States
Alma materUniversity College Dublin (MB, MD, PhD)
Harvard University/Massachusetts Institute of Technology (MMSc)
Known forDiscovery of the C9orf72 repeat expansion
AwardsNIH Director's award
Sheila Essey Award
Potamkin Prize
Scientific career
FieldsAmyotrophic lateral sclerosis
frontotemporal dementia
genetics
InstitutionsNational Institute on Aging
Johns Hopkins University

Education

Traynor received his medical degree (MB, BCh, BAO) from University College Dublin in 1993. In 2000, he completed his Medical Doctorate (MD) at University College Dublin in epidemiology and genetics. He then moved to Boston, where he was a neurology resident at Brigham and Women's Hospital and Massachusetts General Hospital. He received his Master of Medical Science (MMSc) in 2004 from Harvard University and the Massachusetts Institute of Technology, as well as a Doctor of Philosophy (PhD) degree in neurogenetics from University College Dublin in 2012.

Awards, prizes, and honors

Notable professional service

References
  1. "Neuromuscular Diseases Research Section". National Institute on Aging. Retrieved 2019-03-26.
  2. Renton, Alan E.; Majounie, Elisa; Waite, Adrian; Simón-Sánchez, Javier; Rollinson, Sara; Gibbs, J. Raphael; Schymick, Jennifer C.; Laaksovirta, Hannu; van Swieten, John C.; Myllykangas, Liisa; Kalimo, Hannu; Paetau, Anders; Abramzon, Yevgeniya; Remes, Anne M.; Kaganovich, Alice; Scholz, Sonja W.; Duckworth, Jamie; Ding, Jinhui; Harmer, Daniel W.; Hernandez, Dena G.; Johnson, Janel O.; Mok, Kin; Ryten, Mina; Trabzuni, Danyah; Guerreiro, Rita J.; Orrell, Richard W.; Neal, James; Murray, Alex; Pearson, Justin; Jansen, Iris E.; Sondervan, David; Seelaar, Harro; Blake, Derek; Young, Kate; Halliwell, Nicola; Callister, Janis Bennion; Toulson, Greg; Richardson, Anna; Gerhard, Alex; Snowden, Julie; Mann, David; Neary, David; Nalls, Michael A.; Peuralinna, Terhi; Jansson, Lilja; Isoviita, Veli-Matti; Kaivorinne, Anna-Lotta; Hölttä-Vuori, Maarit; Ikonen, Elina; Sulkava, Raimo; Benatar, Michael; Wuu, Joanne; Chiò, Adriano; Restagno, Gabriella; Borghero, Giuseppe; Sabatelli, Mario; Heckerman, David; Rogaeva, Ekaterina; Zinman, Lorne; Rothstein, Jeffrey D.; Sendtner, Michael; Drepper, Carsten; Eichler, Evan E.; Alkan, Can; Abdullaev, Ziedulla; Pack, Svetlana D.; Dutra, Amalia; Pak, Evgenia; Hardy, John; Singleton, Andrew; Williams, Nigel M.; Heutink, Peter; Pickering-Brown, Stuart; Morris, Huw R.; Tienari, Pentti J.; Traynor, Bryan J. (2011). "A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD". Neuron. 72 (2): 257–268. doi:10.1016/j.neuron.2011.09.010. ISSN 0896-6273. PMC 3200438.
  3. Johnson, Janel O.; Mandrioli, Jessica; Benatar, Michael; Abramzon, Yevgeniya; Van Deerlin, Vivianna M.; Trojanowski, John Q.; Gibbs, J. Raphael; Brunetti, Maura; Gronka, Susan; Wuu, Joanne; Ding, Jinhui; McCluskey, Leo; Martinez-Lage, Maria; Falcone, Dana; Hernandez, Dena G.; Arepalli, Sampath; Chong, Sean; Schymick, Jennifer C.; Rothstein, Jeffrey; Landi, Francesco; Wang, Yong-Dong; Calvo, Andrea; Mora, Gabriele; Sabatelli, Mario; Monsurrò, Maria Rosaria; Battistini, Stefania; Salvi, Fabrizio; Spataro, Rossella; Sola, Patrizia; Borghero, Giuseppe; Galassi, Giuliana; Scholz, Sonja W.; Taylor, J. Paul; Restagno, Gabriella; Chiò, Adriano; Traynor, Bryan J. (2010). "Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS". Neuron. 68 (5): 857–864. doi:10.1016/j.neuron.2010.11.036. ISSN 0896-6273. PMC 3032425.
  4. Johnson, Janel O; Pioro, Erik P; Boehringer, Ashley; Chia, Ruth; Feit, Howard; Renton, Alan E; Pliner, Hannah A; Abramzon, Yevgeniya; Marangi, Giuseppe; Winborn, Brett J; Gibbs, J Raphael; Nalls, Michael A; Morgan, Sarah; Shoai, Maryam; Hardy, John; Pittman, Alan; Orrell, Richard W; Malaspina, Andrea; Sidle, Katie C; Fratta, Pietro; Harms, Matthew B; Baloh, Robert H; Pestronk, Alan; Weihl, Conrad C; Rogaeva, Ekaterina; Zinman, Lorne; Drory, Vivian E; Borghero, Giuseppe; Mora, Gabriele; Calvo, Andrea; Rothstein, Jeffrey D; Drepper, Carsten; Sendtner, Michael; Singleton, Andrew B; Taylor, J Paul; Cookson, Mark R; Restagno, Gabriella; Sabatelli, Mario; Bowser, Robert; Chiò, Adriano; Traynor, Bryan J (2014). "Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis". Nature Neuroscience. 17 (5): 664–666. doi:10.1038/nn.3688. ISSN 1097-6256. PMC 4000579.
  5. Renton, Alan E.; Pliner, Hannah A.; Provenzano, Carlo; Evoli, Amelia; Ricciardi, Roberta; Nalls, Michael A.; Marangi, Giuseppe; Abramzon, Yevgeniya; Arepalli, Sampath; Chong, Sean; Hernandez, Dena G.; Johnson, Janel O.; Bartoccioni, Emanuela; Scuderi, Flavia; Maestri, Michelangelo; Gibbs, J. Raphael; Errichiello, Edoardo; Chiò, Adriano; Restagno, Gabriella; Sabatelli, Mario; Macek, Mark; Scholz, Sonja W.; Corse, Andrea; Chaudhry, Vinay; Benatar, Michael; Barohn, Richard J.; McVey, April; Pasnoor, Mamatha; Dimachkie, Mazen M.; Rowin, Julie; Kissel, John; Freimer, Miriam; Kaminski, Henry J.; Sanders, Donald B.; Lipscomb, Bernadette; Massey, Janice M.; Chopra, Manisha; Howard, James F.; Koopman, Wilma J.; Nicolle, Michael W.; Pascuzzi, Robert M.; Pestronk, Alan; Wulf, Charlie; Florence, Julaine; Blackmore, Derrick; Soloway, Aimee; Siddiqi, Zaeem; Muppidi, Srikanth; Wolfe, Gil; Richman, David; Mezei, Michelle M.; Jiwa, Theresa; Oger, Joel; Drachman, Daniel B.; Traynor, Bryan J. (2015). "A Genome-Wide Association Study of Myasthenia Gravis". JAMA Neurology. 72 (4): 396. doi:10.1001/jamaneurol.2014.4103. ISSN 2168-6149.
  6. "Derek Denny-Brown Neurological Scholar Award | American Neurological Association (ANA)". myana.org. Retrieved 2019-03-26.
  7. "Wings Over Wall Street - Awards". wingsoverwallstreet.org. Retrieved 2019-03-26.
  8. "ALS Association".
  9. "American Academy of Neurology".
  10. "Amyotrophic Lateral Sclerosis Research Program, Programmatic Panels; Congressionally Directed Medical Research Programs". cdmrp.army.mil. Retrieved 2019-03-26.
  11. "Bryan Traynor - Google Scholar Citations". scholar.google.com. Retrieved 2019-03-26.
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