BTB/POZ domain

The BTB/POZ domain is a common structural domain contained within some proteins.

BTB/POZ domain
Structure of the BTB domain from PLZF.[1]
Identifiers
SymbolBTB
PfamPF00651
InterProIPR013069
PROSITEPS50097
SCOPe1buo / SUPFAM

The BTB (for BR-C, ttk and bab)[2] or POZ (for Pox virus and Zinc finger)[3] domain is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the Kelch motif and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation.[3] The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule.[1] BTB/POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT.[4][5][6] The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

References
  1. Ahmad KF, Engel CK, Privé GG (October 1998). "Crystal structure of the BTB domain from PLZF". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12123–8. doi:10.1073/pnas.95.21.12123. PMC 22795. PMID 9770450.
  2. Zollman S, Godt D, Privé GG, Couderc JL, Laski FA (October 1994). "The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10717–21. doi:10.1073/pnas.91.22.10717. PMC 45093. PMID 7938017.
  3. Bardwell VJ, Treisman R (July 1994). "The POZ domain: a conserved protein-protein interaction motif". Genes Dev. 8 (14): 1664–77. doi:10.1101/gad.8.14.1664. PMID 7958847.
  4. Deweindt C, Albagli O, Bernardin F, Dhordain P, Quief S, Lantoine D, Kerckaert JP, Leprince D (December 1995). "The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain". Cell Growth Differ. 6 (12): 1495–503. PMID 9019154.
  5. Huynh KD, Bardwell VJ (November 1998). "The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT". Oncogene. 17 (19): 2473–84. doi:10.1038/sj.onc.1202197. PMID 9824158.
  6. Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306.
This article incorporates text from the public domain Pfam and InterPro: IPR013069
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