BCL6B

BCL6B
Identifiers
Aliases	BCL6B, BAZF, ZBTB28, ZNF62, B-cell CLL/lymphoma 6B, B cell CLL/lymphoma 6B, transcription repressor, BCL6B transcription repressor
External IDs	OMIM: 608992 MGI: 1278332 HomoloGene: 7243 GeneCards: BCL6B
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	7,030,290 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	70,229,798 bp[2]
Gene ontology
Molecular function	• DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • metal ion binding; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001948 protein binding;
Cellular component	• cell nucleus;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • type 2 immune response; • regulation of cell proliferation; • regulation of inflammatory response; • regulation of cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	255877
	12029
	ENSG00000161940
	ENSMUSG00000000317
	Q8N143
	O88282
	NM_181844
	NM_007528
	NP_862827; NP_862827.1
	NP_031554
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell CLL/lymphoma 6 member B protein is a protein that in humans is encoded by the BCL6B gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000161940 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000317 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Okabe S, Fukuda T, Ishibashi K, Kojima S, Okada S, Hatano M, Ebara M, Saisho H, Tokuhisa T (Jul 1998). "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor". Molecular and Cellular Biology. 18 (7): 4235–44. PMC 109007. PMID 9632807.
"Entrez Gene: BCL6B B-cell CLL/lymphoma 6, member B (zinc finger protein)".

Human BCL6B genome location and BCL6B gene details page in the UCSC Genome Browser.

Sakashita C, Fukuda T, Okabe S, Kobayashi H, Hirosawa S, Tokuhisa T, Miyasaka N, Miura O, Miki T (Mar 2002). "Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene". Biochemical and Biophysical Research Communications. 291 (3): 567–73. doi:10.1006/bbrc.2002.6481. PMID 11855826.
Fitzgibbon J, Neat MJ, Jones L, Foot N, Lister TA, Gupta RK (2000). "Assignment of B-cell lymphoma 6, member B (zinc finger protein) gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 218–9. doi:10.1159/000015617. PMID 10965127.
Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Nov 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Aug 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.

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