BCAS1

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.[5][6]

BCAS1
Identifiers
AliasesBCAS1, AIBC1, NABC1, breast carcinoma amplified sequence 1, brain enriched myelin associated protein 1, PMES-2
External IDsOMIM: 602968 MGI: 1924210 HomoloGene: 2714 GeneCards: BCAS1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.2Start53,936,777 bp[1]
End54,070,594 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8537

76960

Ensembl

ENSG00000064787

ENSMUSG00000013523

UniProt

O75363

Q80YN3

RefSeq (mRNA)

NM_001164369
NM_029815

RefSeq (protein)

NP_001157841
NP_084091

Location (UCSC)Chr 20: 53.94 – 54.07 MbChr 2: 170.35 – 170.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000064787 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000013523 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
  6. "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.