Athel Cornish-Bowden

Athel Cornish-Bowden is a biochemist known for his numerous textbooks, particularly those on enzyme kinetics and his work on metabolic control analysis.

Athel Cornish-Bowden
Born(1943-04-03)April 3, 1943
Ashburton, England
Known forEnzyme Kinetics, Metabolic Control Analysis
Websitebip.cnrs-mrs.fr/bip10/homepage.htm

Education and career

Athel Cornish-Bowden worked on pepsin catalysis.[1]. This began a life long pursuit of work on enzyme catalysis[2] and in later years work on the control of metabolism[3]. More recently he has also turned his attention to work related to the origin and nature of life[4]. He worked with Daniel E. Koshland Jr.[5] and Jeremy R. Knowles[6].

Research

Cornish-Bowden has authored over 200 peer-reviewed papers and nine textbooks on topics related to enzyme kinetics, mathematics and historical perspectives in science. Cornish-Bowden's research can be divided into three primary areas: Enzyme kinetics, metabolic control and the origin of life. The following lists some of the topics and selected references to the work carried out and published by Cornish-Bowden:

Mechanisms of Pepsin Catalysis[7][8][9]

Binding of ligands to Proteins[10][11][12][13]

Kinetics of nitrite reductase[14][15][16]

Kinetics of nitrate reductase[17]

The evolution of macromolecules[18][19]

Properties of multienzyme systems[20][21][22][23][24]

The theory of self-organizing systems[25][26][27][28][29]

His current interests include the definition of life and the capacity for life to self-organize.

Cornish-Bowden is most well known for his introduction of the direct-linear plot for estimating enzyme parameters[30], his work on Hexokinase evolution and kinetics[31], and his insight into the control and regulation of metabolism[32]

Selected publications
  • Cornish-Bowden, Athel; Eisenthal, Robert (1974). "The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters". Biochemical Journal. 139 (3): 715–720. doi:10.1042/bj1390715. PMC 1166335. PMID 4854723. Cited 1716 times (Aug, 2019)
  • Cornish-Bowden, A (14 July 1986). "Why is uncompetitive inhibition so rare? A possible explanation, with implications for the design of drugs and pesticides". FEBS Letters. 203 (1): 3–6. doi:10.1016/0014-5793(86)81424-7. PMID 3720956. Cited 137 times (Aug 2019)
  • Eisenthal, R; Cornish-Bowden, A (6 March 1998). "Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness". The Journal of Biological Chemistry. 273 (10): 5500–5. doi:10.1074/jbc.273.10.5500. PMID 9488673. Cited 96 times (Aug 2019)
  • Cárdenas, ML; Cornish-Bowden, A; Ureta, T (5 March 1998). "Evolution and regulatory role of the hexokinases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1401 (3): 242–64. doi:10.1016/s0167-4889(97)00150-x. PMID 9540816. Cited 287 times (Aug 2019)
  • Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS Letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248. Cited 203 times (Aug 2019)
  • Hucka, M; Finney, A; Sauro, HM; Bolouri, H; Doyle, JC; Kitano, H; Arkin, AP; Bornstein, BJ; Bray, D; Cornish-Bowden, A; Cuellar, AA; Dronov, S; Gilles, ED; Ginkel, M; Gor, V; Goryanin, II; Hedley, WJ; Hodgman, TC; Hofmeyr, JH; Hunter, PJ; Juty, NS; Kasberger, JL; Kremling, A; Kummer, U; Le Novère, N; Loew, LM; Lucio, D; Mendes, P; Minch, E; Mjolsness, ED; Nakayama, Y; Nelson, MR; Nielsen, PF; Sakurada, T; Schaff, JC; Shapiro, BE; Shimizu, TS; Spence, HD; Stelling, J; Takahashi, K; Tomita, M; Wagner, J; Wang, J; SBML, Forum. (1 March 2003). "The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models". Bioinformatics (Oxford, England). 19 (4): 524–31. doi:10.1093/bioinformatics/btg015. PMID 12611808. Cited 3057 times (Aug 2019)
  • Letelier, JC; Soto-Andrade, J; Guíñez Abarzúa, F; Cornish-Bowden, A; Luz Cárdenas, M (21 February 2006). "Organizational invariance and metabolic closure: analysis in terms of (M,R) systems". Journal of Theoretical Biology. 238 (4): 949–61. doi:10.1016/j.jtbi.2005.07.007. PMID 16122760. Cited 269 times (Aug 2019)
  • Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744. Cited 3120 times (Aug 2012)
  • Cornish-Bowden, A; Cárdenas, ML (7 December 2017). "Life before LUCA". Journal of Theoretical Biology. 434: 68–74. doi:10.1016/j.jtbi.2017.05.023. PMID 28536033. Cited 10 times (Aug 2019)

Books
  • Cornish-Bowden, Athel (1976). Principles of Enzyme Kinetics. London: Butterworths. ISBN 0408707216.
  • Cornish-Bowden, Athel (1979). Fundamentals of Enzyme Kinetics. London: Butterworths.
  • Cornish-Bowden, Athel (1995). Fundamentals of Enzyme Kinetics (2 ed.). London: Butterworths. ISBN 1-85578-072-0.
  • Cornish-Bowden, Athel (1996). Analysis of Enzyme Kinetic Datas (4 ed.). London: Oxford University Press. ISBN 0-19-854877-X.
  • Cornish-Bowden, Athel (1999). Basic Mathematics for Biochemists (2 ed.). Oxford and New York: Oxford University Press. ISBN 0-19-854877-X.
  • Cornish-Bowden, Athel (2004). Fundamentals of Enzyme Kinetics (3 ed.). London: Butterworths. ISBN 0408707216.
  • Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744.
  • Cornish-Bowden, Athel (2016). Biochemical Evolution: the Pursuit of Perfection (2 ed.). Garland Science. ISBN 978-0-8153-4552-7.

References
  1. Cornish-Bowden, AJ; Greenwell, P; Knowles, JR (June 1969). "The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical Journal. 113 (2): 369–75. doi:10.1042/bj1130369. PMC 1184644. PMID 4897200.
  2. Cornish-Bowden, A; Connolly, BA; Gregoriou, M; Holroyde, MJ; Storer, AC; Trayer, IP (December 1979). "Mammalian hexokinases: a system for the study of co-operativity in monomeric enzymes". Archivos de Biologia y Medicina Experimentales. 12 (5): 581–5. PMID 552244.
  3. Hofmeyr, JH; Cornish-Bowden, A (15 August 1991). "Quantitative assessment of regulation in metabolic systems". European Journal of Biochemistry. 200 (1): 223–36. doi:10.1111/j.1432-1033.1991.tb21071.x. PMID 1879427.
  4. Cornish-Bowden, A; Cárdenas, ML (7 December 2017). "Life before LUCA". Journal of Theoretical Biology. 434: 68–74. doi:10.1016/j.jtbi.2017.05.023. PMID 28536033.
  5. Cornish-Bowden, A; Koshland DE, Jr (18 August 1970). "A general method for the quantitative determination of saturation curves for multisubunit proteins". Biochemistry. 9 (17): 3325–36. doi:10.1021/bi00819a006. PMID 4330854.
  6. Cornish-Bowden, AJ; Greenwell, P; Knowles, JR (June 1969). "The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical Journal. 113 (2): 369–75. doi:10.1042/bj1130369. PMC 1184644. PMID 4897200.
  7. Cornish-Bowden, AJ; Knowles, JR (June 1969). "The pH-dependence of pepsin-catalysed reactions". The Biochemical Journal. 113 (2): 353–62. doi:10.1042/bj1130353. PMC 1184642. PMID 4897198.
  8. Cornish-Bowden, AJ; Knowles, JR (June 1969). "The pH-dependence of pepsin-catalysed reactions". The Biochemical Journal. 113 (2): 353–62. doi:10.1042/bj1130353. PMC 1184642. PMID 4897198.
  9. Cornish-Bowden, AJ; Greenwell, P; Knowles, JR (June 1969). "The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical Journal. 113 (2): 369–75. doi:10.1042/bj1130369. PMC 1184644. PMID 4897200.
  10. Cornish-Bowden, A; Koshland DE, Jr (10 December 1970). "The influence of binding domains on the nature of subunit interactions in oligomeric proteins. Application to unusual kinetic and binding patterns". The Journal of Biological Chemistry. 245 (23): 6241–50. PMID 5484808.
  11. Cornish-Bowden, A; Koshland DE, Jr (18 August 1970). "A general method for the quantitative determination of saturation curves for multisubunit proteins". Biochemistry. 9 (17): 3325–36. doi:10.1021/bi00819a006. PMID 4330854.
  12. Cornish-Bowden, A; Koshland DE, Jr (25 June 1975). "Diagnostic uses of the Hill (Logit and Nernst) plots". Journal of Molecular Biology. 95 (2): 201–12. doi:10.1016/0022-2836(75)90390-3. PMID 171413.
  13. Cornish-Bowden, A (May 1975). "Letter: The physiological significance of negative co-operativity". Journal of Theoretical Biology. 51 (1): 233–5. doi:10.1016/0022-5193(75)90149-6. PMID 1142781.
  14. Coleman, KJ; Cornish-Bowden, A; Cole, JA (1 November 1978). "Purification and properties of nitrite reductase from Escherichia coli K12". The Biochemical Journal. 175 (2): 483–93. doi:10.1042/bj1750483. PMC 1186095. PMID 217342.
  15. Jackson, RH; Cole, JA; Cornish-Bowden, A (1 May 1982). "The steady state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K12. The reduction of single-electron acceptors". The Biochemical Journal. 203 (2): 505–10. doi:10.1042/bj2030505. PMC 1158256. PMID 6288003.
  16. Jackson, RH; Cole, JA; Cornish-Bowden, A (1 May 1982). "The steady state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K12. The reduction of single-electron acceptors". The Biochemical Journal. 203 (2): 505–10. doi:10.1042/bj2030505. PMC 1158256. PMID 6288003.
  17. Buc, J; Santini, CL; Blasco, F; Giordani, R; Cárdenas, ML; Chippaux, M; Cornish-Bowden, A; Giordano, G (15 December 1995). "Kinetic studies of a soluble alpha beta complex of nitrate reductase A from Escherichia coli. Use of various alpha beta mutants with altered beta subunits". European Journal of Biochemistry. 234 (3): 766–72. doi:10.1111/j.1432-1033.1995.766_a.x. PMID 8575433.
  18. Cornish-Bowden, A (15 February 1976). "The effect of natural selection on enzymic catalysis". Journal of Molecular Biology. 101 (1): 1–9. doi:10.1016/0022-2836(76)90062-0. PMID 1255718.
  19. Cornish-Bowden, A (1985). "Are introns structural elements or evolutionary debris?". Nature. 313 (6002): 434–5. doi:10.1038/313434b0. PMID 3969152.
  20. Hofmeyr, JH; Cornish-Bowden, A (15 August 1991). "Quantitative assessment of regulation in metabolic systems". European Journal of Biochemistry. 200 (1): 223–36. doi:10.1111/j.1432-1033.1991.tb21071.x. PMID 1879427.
  21. Cornish-Bowden, A; Hofmeyr, JH (1 March 1994). "Determination of control coefficients in intact metabolic systems". The Biochemical Journal. 298 ( Pt 2) (2): 367–75. doi:10.1042/bj2980367. PMC 1137949. PMID 8135743.
  22. Hofmeyr, JH; Cornish-Bowden, A (7 October 1996). "Co-response analysis: a new experimental strategy for metabolic control analysis". Journal of Theoretical Biology. 182 (3): 371–80. doi:10.1006/jtbi.1996.0176. PMID 8944170.
  23. Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS Letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248.
  24. Cornish-Bowden, A; Hofmeyr, JH (21 May 2002). "The role of stoichiometric analysis in studies of metabolism: an example". Journal of Theoretical Biology. 216 (2): 179–91. doi:10.1006/jtbi.2002.2547. PMID 12079370.
  25. Cornish-Bowden, A; Cárdenas, ML; Letelier, JC; Soto-Andrade, J; Abarzúa, FG (December 2004). "Understanding the parts in terms of the whole". Biology of the Cell. 96 (9): 713–7. doi:10.1016/j.biolcel.2004.06.006. PMID 15567526.
  26. Cornish-Bowden, A; Cárdenas, ML (October 2007). "Organizational invariance in (M,R)-systems". Chemistry & Biodiversity. 4 (10): 2396–406. doi:10.1002/cbdv.200790195. PMID 17955465.
  27. Cornish-Bowden, A; Cárdenas, ML (7 June 2008). "Self-organization at the origin of life". Journal of Theoretical Biology. 252 (3): 411–8. doi:10.1016/j.jtbi.2007.07.035. PMID 17889904.
  28. Cárdenas, ML; Letelier, JC; Gutierrez, C; Cornish-Bowden, A; Soto-Andrade, J (7 March 2010). "Closure to efficient causation, computability and artificial life". Journal of Theoretical Biology. 263 (1): 79–92. doi:10.1016/j.jtbi.2009.11.010. PMID 19962389.
  29. Cárdenas, ML; Letelier, JC; Gutierrez, C; Cornish-Bowden, A; Soto-Andrade, J (7 March 2010). "Closure to efficient causation, computability and artificial life". Journal of Theoretical Biology. 263 (1): 79–92. doi:10.1016/j.jtbi.2009.11.010. PMID 19962389.
  30. Eisenthal, R; Cornish-Bowden, A (June 1974). "The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters". The Biochemical Journal. 139 (3): 715–20. doi:10.1042/bj1390715. PMC 1166335. PMID 4854723.
  31. Cárdenas, ML; Cornish-Bowden, A; Ureta, T (5 March 1998). "Evolution and regulatory role of the hexokinases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1401 (3): 242–64. doi:10.1016/s0167-4889(97)00150-x. PMID 9540816.
  32. Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS Letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248.
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