AZIN2

AZIN2
Identifiers
Aliases	AZIN2, ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs	OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	33,123,492 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	128,962,442 bp[2]
Gene ontology
Molecular function	• putrescine transmembrane transporter activity; • catalytic activity; • GO:0001948 protein binding; • ornithine decarboxylase activator activity; • arginine decarboxylase activity; • ornithine decarboxylase activity;
Cellular component	• transport vesicle; • cytoplasm; • mitochondrion; • trans-Golgi network; • cell projection; • Golgi apparatus; • cell nucleus; • axon; • granular vesicle; • membrane; • dendrite; • perinuclear region of cytoplasm; • cis-Golgi network; • cytoplasmic vesicle; • perikaryon; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • cytosol;
Biological process	• positive regulation of polyamine transmembrane transport; • spermatogenesis; • putrescine transport; • ornithine metabolic process; • putrescine biosynthetic process from ornithine; • trans-Golgi network membrane organization; • agmatine biosynthetic process; • positive regulation of catalytic activity; • polyamine biosynthetic process; • negative regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	113451
	242669
	ENSG00000142920
	ENSMUSG00000028789
	Q96A70
	Q8BVM4
NM_001293562; NM_001301823; NM_001301824; NM_001301825; NM_001301826;
	NM_052998; NM_001350398; NM_001350399; NM_001350400; NM_001350401; NM_001350402; NM_001376722; NM_001376724; NM_001376725; NM_001376727; NM_001376729; NM_001376730; NM_001376732
	NM_001301841; NM_172875
NP_001280491; NP_001288752; NP_001288753; NP_001288754; NP_001288755;
	NP_443724; NP_001337327; NP_001337328; NP_001337329; NP_001337330; NP_001337331; NP_001363651; NP_001363653; NP_001363654; NP_001363656; NP_001363658; NP_001363659; NP_001363661
	NP_001288770; NP_766463
	Wikidata
View/Edit Human	View/Edit Mouse

Antizyme inhibitor 2 (AzI2) also known as arginine decarboxylase (ADC) is an enzyme that in humans is encoded by the AZIN2 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
"Entrez Gene: ADC arginine decarboxylase".

External links

Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.
Human AZIN2 genome location and AZIN2 gene details page in the UCSC Genome Browser.

Nagase T, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Coleman CS, Hu G, Pegg AE (2004). "Putrescine biosynthesis in mammalian tissues". Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". Int. J. Cancer. 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase". Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11587527-5] Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.

[pmid14738999-6] Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.

[entrez-7] "Entrez Gene: ADC arginine decarboxylase".

AZIN2

References

External links

Further reading