AS04

Adjuvant System 04 (AS04) is a mixture of 4 agonist monophosphoryl lipid A (MPL) and aluminum hydroxide. It is one of the ingredients of the human papillomavirus vaccine (HPV). Sientists studied AS04-adjuvanted HPV vaccine and it shows high and justified immune response against to HPV antigens.[1] Not only that but the patients who took HPV-16/18 AS04-adjuvanted vaccine previously showed that on the second or subsequent doses immune responded stronger and rapidly, which tells that it builds immune memory in the body.[2]

AS04 (Aka. "Adjuvant System 04") is a trade name for combination of adjuvants used in various vaccine product by GlaxoSmithKline (GSK), in particular the Fendrix Hepatitis B vaccine. It consists of aluminum hydroxide and monophosphoryl lipid A (MPL). Furthermore, it is the successor of AS03 which is a Squalene based adjuvant approved for pandemic vaccine by the EMA.[3]

References
  1. Morel, Sandra (2011). "BioDrugs". 25: 217–226. Cite journal requires |journal= (help)
  2. Mocicki, A (2012). Vaccine. 31. pp. 234–241.
  3. Plotkin; et al. Vaccines 6th ed. Elsevier Saunders. pp. 58–79. ISBN 978-1-4557-0090-5.

See also
  • 2009 flu pandemic


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