ARFIP2

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]

ARFIP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDsOMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start6,474,683 bp[1]
End6,481,479 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23647

76932

Ensembl

ENSG00000132254

ENSMUSG00000030881

UniProt

P53365

Q8K221

RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)

NP_084078

Location (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.63 – 105.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References
  1. GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. PMC 452058. PMID 8670882.
  6. Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  7. "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  9. Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  10. Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.

Further reading
  • D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  • Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
  • Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  • Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (March 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
  • Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  • Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (June 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
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