ANKRD23

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.[5][6]

ANKRD23
Identifiers
AliasesANKRD23, DARP, MARP3, ankyrin repeat domain 23
External IDsOMIM: 610736 MGI: 1925571 HomoloGene: 14025 GeneCards: ANKRD23
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q11.2Start96,824,526 bp[1]
End96,857,934 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

200539

78321

Ensembl

ENSG00000163126

ENSMUSG00000067653

UniProt

Q86SG2

Q812A3

RefSeq (mRNA)

NM_144994

NM_153502
NM_001310521

RefSeq (protein)

NP_659431

NP_001297450
NP_705722

Location (UCSC)Chr 2: 96.82 – 96.86 MbChr 1: 36.53 – 36.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.[6]

Interactions

ANKRD23 has been shown to interact with Titin[7] and MYPN.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163126 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067653 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.
  6. "Entrez Gene: ANKRD23 ankyrin repeat domain 23".
  7. Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.

Further reading

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