AMY2B

Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.[5][6]

AMY2B
Identifiers
AliasesAMY2B, AMY2, AMY3, HXA, amylase, alpha 2B (pancreatic), amylase alpha 2B (pancreatic), amylase alpha 2B
External IDsOMIM: 104660 MGI: 3714985 HomoloGene: 134663 GeneCards: AMY2B
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p21.1Start103,553,815 bp[1]
End103,579,534 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

280

100043686

Ensembl

ENSG00000240038

ENSMUSG00000093931

UniProt

P19961

P00688

RefSeq (mRNA)

NM_020978

NM_001160151

RefSeq (protein)

NP_066188

NP_001153622
NP_001036176
NP_001153624
NP_001153623

Location (UCSC)Chr 1: 103.55 – 103.58 MbChr 3: 113.31 – 113.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside] bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[6]

References
  1. GRCh38: Ensembl release 89: ENSG00000240038 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000093931 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Omichi K, Hase S (December 1993). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1203 (2): 224–9. doi:10.1016/0167-4838(93)90087-8. PMID 8268204.
  6. "Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)".

Further reading
  • Kaczmarek MJ, Rosenmund H (August 1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clinica Chimica Acta; International Journal of Clinical Chemistry. 79 (1): 69–73. doi:10.1016/0009-8981(77)90462-4. PMID 890964.
  • Groot PC, Mager WH, Henriquez NV, Pronk JC, Arwert F, Planta RJ, Eriksson AW, Frants RR (September 1990). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. doi:10.1016/0888-7543(90)90230-R. PMID 2081604.
  • Yokouchi H, Horii A, Emi M, Tomita N, Doi S, Ogawa M, Mori T, Matsubara K (June 1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". Gene. 90 (2): 281–6. doi:10.1016/0378-1119(90)90191-S. PMID 2401405.
  • Gumucio DL, Wiebauer K, Caldwell RM, Samuelson LC, Meisler MH (March 1988). "Concerted evolution of human amylase genes". Molecular and Cellular Biology. 8 (3): 1197–205. doi:10.1128/mcb.8.3.1197. PMC 363264. PMID 2452973.
  • Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (September 1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Research. 16 (17): 8261–76. doi:10.1093/nar/16.17.8261. PMC 338557. PMID 2458567.
  • Tomita N, Horii A, Doi S, Yokouchi H, Shiosaki K, Higashiyama M, Matsuura N, Ogawa M, Mori T, Matsubara K (March 1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor". Gene. 76 (1): 11–8. doi:10.1016/0378-1119(89)90003-6. PMID 2701942.
  • Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (July 1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. doi:10.1016/0888-7543(89)90083-9. PMID 2788608.
  • Groot PC, Bleeker MJ, Pronk JC, Arwert F, Mager WH, Planta RJ, Eriksson AW, Frants RR (May 1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Research. 16 (10): 4724. doi:10.1093/nar/16.10.4724. PMC 336663. PMID 3260028.
  • Tricoli JV, Shows TB (March 1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somatic Cell and Molecular Genetics. 10 (2): 205–10. doi:10.1007/BF01534909. PMID 6608795.
  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Aughsteen AA (May 2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi Medical Journal. 22 (5): 410–5. PMID 11376382.
  • Koyama I, Komine S, Iino N, Hokari S, Igarashi S, Alpers DH, Komoda T (July 2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". Clinica Chimica Acta; International Journal of Clinical Chemistry. 309 (1): 73–83. doi:10.1016/S0009-8981(01)00501-0. PMID 11408008.
  • Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (September 2004). "Detection of large-scale variation in the human genome". Nature Genetics. 36 (9): 949–51. doi:10.1038/ng1416. PMID 15286789.


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