ALG11

ALG11
Identifiers
Aliases	ALG11, CDG1P, GT8, alpha-1,2-mannosyltransferase, ALG11 alpha-1,2-mannosyltransferase
External IDs	OMIM: 613666 MGI: 2142632 HomoloGene: 68893 GeneCards: ALG11
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	52,033,600 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	22,071,627 bp[2]
Gene ontology
Molecular function	• transferase activity; • transferase activity, transferring glycosyl groups; • GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum; • membrane; • endoplasmic reticulum membrane;
Biological process	• mannosylation; • oligosaccharide-lipid intermediate biosynthetic process; • protein glycosylation in endoplasmic reticulum; • protein N-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	440138
	207958
	ENSG00000253710
	ENSMUSG00000063362
	Q2TAA5
	Q3TZM9
	NM_001004127
	NM_001243161; NM_183142
	NP_001004127
	NP_001230090; NP_898965
	Wikidata
View/Edit Human	View/Edit Mouse

Asparagine-linked glycosylation protein 11 is an enzyme encoded by the ALG11 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000253710 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000063362 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: asparagine-linked glycosylation 11".
Cipollo, JF; Trimble, RB; Chi, JH; Yan, Q; Dean, N (2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi:10.1074/jbc.m010896200. PMID 11278778.
Gao, XD; Nishikawa, A; Dean, N. (Jun 2004). "Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. 2004". Glycobiology. 14 (6): 559–70. CiteSeerX 10.1.1.572.6611. doi:10.1093/glycob/cwh072. PMID 15044395.

Human ALG11 genome location and ALG11 gene details page in the UCSC Genome Browser.

Rohozinski J, Lamb DJ, Bishop CE (2006). "UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man". Biol. Reprod. 74 (4): 644–51. doi:10.1095/biolreprod.105.046698. PMID 16354793.
Rind N, Schmeiser V, Thiel C, et al. (2010). "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip". Hum. Mol. Genet. 19 (8): 1413–24. doi:10.1093/hmg/ddq016. PMID 20080937.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N (June 2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi:10.1074/jbc.M010896200. PMID 11278778.

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