AG 489

AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.[1] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]

AG 489
Names
IUPAC name
N-[3-[3-[3-[4-(3-aminopropylamino) butylamino] propylamino]propyl-hydroxyamino] propyl]-2-(1H-indol-3-yl)acetamide
Other names
Agatoxin 489
Identifiers
3D model (JSmol)
ChemSpider
Properties
C26H47N7O2
Molar mass 489.69708
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References

  1. Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.
  2. Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.

See also


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