AGH-107

AGH-107
Identifiers
	IUPAC name 3-(3-ethylimidazol-4-yl)-5-iodo-1H-indole;
PubChem CID	138691314;
Chemical and physical data
Formula	C13H12IN3
Molar mass	337.164 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCn1cncc1-c1c[nH]c2ccc(I)cc12;

AGH-107 is a potent and selective, water soluble and brain penetrant full agonist at the 5HT₇ serotonin receptor.[1] The compound is one of the few examples of low-basicity aminergic receptor agonists, which may be a contributing factor in its high selectivity over the related central nervous system targets. The compound readily crosses the blood-brain barrier after intraperitoneal administration and was found to reverse the impairment in novel object recognition caused by MK-801 in mice.

References

Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC 5431432. PMID 28473721.

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[1] Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC 5431432. PMID 28473721.