AE1/AE3
AE1/AE3 is an antibody cocktail that is used in immunohistochemistry, being generally positive in carcinomas (cancers of epithelial origin).[1]
Targets
The antibody cocktail binds to cytokeratin 1 - 8, 10, 14 - 16 and 19 (but not CK17 or CK18).[1] It is therefore used as a marker of carcinomas, such as depth of invasion and metastases.[1]
It may cross-react with GFAP, leading to aberrant staining of glial tumors such as ependymoma, glioblastoma and schwannoma.[1] It may also stain myofibroblasts and smooth muscle cells.[1] Furthermore, it may stain nodal epithelial cells that has contaminated a tumor from recent biopsy.[1]
References
- "Stains - Cytokeratin AE1 / AE3". PathologyOutlines. 2013-07-01. Revised: 26 November 2019
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