3-hydroxyacyl-CoA dehydratase 2

HACD2
Identifiers
Aliases	HACD2, PTPLB, 3-hydroxyacyl-CoA dehydratase 2
External IDs	OMIM: 615939 MGI: 1918007 HomoloGene: 23409 GeneCards: HACD2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	123,585,053 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	35,109,177 bp[2]
Gene ontology
Molecular function	• protein tyrosine phosphatase activity; • enzyme binding; • 3-hydroxyacyl-CoA dehydratase activity; • GO:0001948 protein binding; • lyase activity; • 3R-hydroxyacyl-CoA dehydratase activity; • 3-hydroxy-behenoyl-CoA dehydratase activity; • 3-hydroxy-lignoceroyl-CoA dehydratase activity; • 3-hydroxy-arachidoyl-CoA dehydratase activity; • very-long-chain 3-hydroxyacyl-CoA dehydratase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane; • integral component of endoplasmic reticulum membrane;
Biological process	• fatty acid elongation; • fatty acid biosynthetic process; • sphingolipid biosynthetic process; • long-chain fatty-acyl-CoA biosynthetic process; • very long-chain fatty acid biosynthetic process; • fatty acid metabolic process; • lipid metabolism; • peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	201562
	70757
	ENSG00000206527
	ENSMUSG00000035376
	Q6Y1H2
	Q9D3B1
	NM_001329783; NM_001329784; NM_001329786; NM_001329787; NM_198402
	NM_023587
	NP_001316712; NP_001316713; NP_001316715; NP_001316716; NP_940684
	NP_076076
	Wikidata
View/Edit Human	View/Edit Mouse

3-hydroxyacyl-CoA dehydratase 2 is a protein that in humans is encoded by the HACD2 gene. [5]

Function

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane.

References

GRCh38: Ensembl release 89: ENSG00000206527 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035376 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: 3-hydroxyacyl-CoA dehydratase 2". Retrieved 2017-09-22.

Wang B, Pelletier J, Massaad MJ, Herscovics A, Shore GC (2004). "The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B". Mol. Cell. Biol. 24 (7): 2767–78. doi:10.1128/mcb.24.7.2767-2778.2004. PMC 371098. PMID 15024066.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206527 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035376 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: 3-hydroxyacyl-CoA dehydratase 2". Retrieved 2017-09-22.

3-hydroxyacyl-CoA dehydratase 2

Function

References

Further reading