2-Tetralone

2-Tetralone is an organic chemical compound with the molecular formula C10H10O. This colourless oil is an intermediate in organic synthesis. It is a ketone derivative of tetralin, a hydrogenated derivative of naphthalene. A related compound is 1-tetralone.

2-Tetralone
Names
IUPAC name
3,4-Dihydro-2(1H)-naphthalenone
Other names
β-Tetralone; 2-Tetralone
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.007.727
EC Number
  • 208-498-3
Properties
C10H10O
Molar mass 146.189 g·mol−1
Appearance Colourless liquid
Density 1.106 g/mL
Melting point 18 °C (64 °F; 291 K)
Boiling point 70–71 °C (158–160 °F; 343–344 K) /0.25 mm
in basic water
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

2-Tetralone is prepared by reductive cleavage of 2-naphthyl ethers.[1]

Applications

2-Tetralone is an intermediate in the synthesis of a variety of pharmaceutical drugs including L-687,384, nepinalone, napamezole,[2] spirodone, and trioxifene.

References

  1. M. D. Soffer, M. P. Bellis, Hilda E. Gellerson, and Roberta A. Stewart "β-Tetralone" Org. Synth. 1952, 32, 97 doi:10.15227/orgsyn.032.0097
  2. Wentland, Mark P.; Bailey, Denis M.; Alexander, E. John; Castaldi, Michael J.; Ferrari, Richard A.; Haubrich, Dean R.; Luttinger, Daniel A.; Perrone, Mark H. (1987). "Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives". Journal of Medicinal Chemistry. 30 (8): 1482–1489. doi:10.1021/jm00391a034.
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