Ubiquilin 4

UBQLN4
Identifiers
Aliases	UBQLN4, A1U, A1Up, C1orf6, CIP75, UBIN, Ubiquilin 4
External IDs	MGI: 2150152 HomoloGene: 41346 GeneCards: UBQLN4
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,053,794 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	88,569,725 bp[2]
Gene ontology
Molecular function	• polyubiquitin modification-dependent protein binding; • protein binding; • identical protein binding;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • autophagosome; • nuclear proteasome complex; • cytosolic proteasome complex; • cytosol; • endoplasmic reticulum membrane; • cytoplasmic vesicle; • endoplasmic reticulum; • cell nucleus;
Biological process	• autophagy; • negative regulation of autophagosome maturation; • regulation of proteasomal ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	56893
	94232
	ENSG00000160803
	ENSMUSG00000008604
	Q9NRR5
	Q99NB8
	NM_001304342; NM_020131
	NM_033526
	NP_001291271; NP_064516
	NP_277068
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.^[5]^[6]^[7] Ubiquilin 4 regulates proteasomal protein degradation.^[8]

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.^[9]

1 2 3 GRCh38: Ensembl release 89: ENSG00000160803 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008604 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.
↑ Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.
↑ Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
↑ Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.
↑ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.

UBQLN4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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