U5 spliceosomal RNA

U5 spliceosomal RNA
Identifiers
Symbol U5
Rfam RF00020
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO 0000351 0000353 0005682 0046540
SO 0000395
PDB structures PDBe

U5 RNA is a non-coding RNA that is a component of both types of known spliceosome.[1] The precise function of this molecule is unknown, though it is known that the 5' loop is required for splice site selection and p220 binding, and that both the 3' stem-loop and the Sm site are important for Sm protein binding and cap methylation. It is possible that U5 spliceosomal RNA is responsible for ligating the two exons together following the cleavage of the intron.[2]

References

  1. ↑ Hinz M, Moore MJ, Bindereif A (August 1996). "Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly". J. Biol. Chem. 271 (31): 19001–19007. doi:10.1074/jbc.271.31.19001. PMID 8702566.
  2. ↑ https://www.researchgate.net/figure/Models-of-RNA-RNA-interactions-in-the-yeast-spliceosome-required-for-the-first-and-second_fig11_6897466

Further reading

  • Zwieb, C (1997). "The uRNA database". Nucleic Acids Res. 25 (1): 102&ndash, 103. doi:10.1093/nar/25.1.102. PMC 146409. PMID 9016512.
  • Thomas, J; Lea K; Zucker-Aprison E; Blumenthal T (1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids Res. 18 (9): 2633&ndash, 2642. doi:10.1093/nar/18.9.2633. PMC 330746. PMID 2339054.


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