Trisomic rescue

Trisomic rescue (also known as trisomy rescue or trisomy zygote rescue) is a genetic phenomenon in which a fertilized ovum containing three copies of a chromosome loses one of these chromosomes to form a normal, diploid chromosome complement.[1] If both of the retained chromosomes come from the same parent, then uniparental disomy results. The mechanism of trisomic rescue has been well confirmed in vivo, and alternative mechanisms that occur in trisomies are rare in comparison.[2]

References

  1. ↑ Balbeur, Samuel; et al. (2 February 2016). "Trisomy rescue mechanism: the case of concomitant mosaic trisomy 14 and maternal uniparental disomy 14 in a 15‐year‐old girl". Clinical Case Reports. 4: 265–271. doi:10.1002/ccr3.501. PMC 4771849. PMID 27014449.
  2. ↑ Chantot-Bastaraud, Sandra; et al. (2017). "Formation of upd(7)mat by trisomic rescue: SNP array typing provides new insights in chromosomal nondisjunction". Molecular Cytogenetics. 10 (28). doi:10.1186/s13039-017-0329-1.


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