P24 protein family
| P24 protein family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TMP21 | ||||||||
| Pfam | PF01105 | ||||||||
| InterPro | IPR015720 | ||||||||
| Membranome | 140 | ||||||||
| |||||||||
P24 protein family is a group of transmembrane proteins that are major components of COPI and COPII-coated vesicles. The family is also known as EMP24/GP25L/p24 family and TMP21-like proteins. The latter naming was after transmembrane emp24 domain-containing protein 10 that was found in the human brain. It was claimed to block the beta-amyloid peptide, which is implicated in the pathogenesis of Alzheimer's Disease.
References
- Protein blocks Alzheimer's toxins in lab tests. CBC News Posted: Apr 27, 2006 1:46 PM ET
- "TMP21 is a presenilin complex component that modulates - but not e-secretase activity." Nature 440: 1208-12.
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