Silver diammine fluoride
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Trade names | FAgamin, Saforide, Advantage Arrest, Cariesop, Bioride, FluoroplatV, Riva Star |
Synonyms | Diammine Silver Fluoride, Diamine silver fluoride (chemically erroneous) |
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Formula | AgF(NH3)2 |
Molar mass | 160.927643 g/mol[1] |
Silver diammine fluoride (also spelled "diamine") is a topical medicament (drug) used to treat and prevent dental caries (cavities) and relieve dentinal hypersensitivity.[2] Silver diammine fluoride has been available in many countries including China, Japan, Germany, Nepal, Brazil, Argentina, New Zealand, Australia and others for many decades.[3] The product was cleared for sale by the U.S. FDA as a class II medical device for the treatment of dentinal hypersensitivity.[4]
Precautions
Silver diammine fluoride (SDF) is a clear liquid that will stain most oxidizable surfaces black upon exposure to light due to the formation of a silver oxide layer. Skin and soft tissue will discolor within minutes to hours after contact and fade away (via surface shedding) within a few days. Dentin and enamel with no demineralization present may receive surface (pellicle) stains that can be removed with pumice, while demineralized tooth structure will stain more permanently black. A mild but transient increase in erythema in the gingiva near the tooth treated by silver diammine fluoride may occur.[5] Silver diammine fluoride is corrosive to metal and glass. Contact with metal produces hydrogen gas and hydrogen fluoride while contact with glass will form silicon tetrafluoride. It is a light-sensitive clear liquid with a strong ammonia smell (when there is excess present) and should be stored in a cool, dark, dry place in a plastic container (LDPE or HDPE).[6]
SDF should not be placed in patients who are allergic to silver or patients suffering from ulcerative gingivitis or stomatitis.[7]
Chemistry and nomenclature
Silver diammine fluoride is a metal ammine complex of silver fluoride. The ammonia ligands are thus "ammine", but the term "amine" is sometimes used incorrectly for this chemical.[8] In addition to that spelling difference, it is sometimes also called "ammoniacal silver fluoride", which is also sometimes improperly spelled as "ammonical silver fluoride".
See also
References
- ↑ "SILVERDIAMINEFLUORIDE (CAS No. 34445-07-3) Suppliers @ ChemicalRegister.com". chemicalregister.com. Retrieved 14 July 2016.
- ↑ Rosenblatt, A.; Stamford, T. C. M.; Niederman, R. (2009). "Silver diamine fluoride: a caries "silver-fluoride bullet"". Journal of Dental Research. 88: 116–125. doi:10.1177/0022034508329406.
- ↑ (PDF) http://www.nationaloralhealthconference.com/docs/presentations/2015/04-29/Jeremy%20Horst.pdf. Missing or empty
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(help) - ↑ http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K102973
- ↑ J.L. Castillo, S. Rivera, T. Aparicio, R. Lazo, T.-C. Aw, L.L. Mancl, P. Milgrom (Nov 2010). "The Short-term Effects of Diammine Silver Fluoride on Tooth Sensitivity a Randomized Controlled Trial". Journal of Dental Research. 90: Issue 2.
- ↑ http://www.elevateoralcare.com/site/images/AASDS082415.pdf
- ↑ Horst, Jeremy A; Ellenikiotis, Hellene; Milgrom, Peter M (January 2016). "UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications, and Consent". Journal of the California Dental Association. 44 (1): 16–28. ISSN 1043-2256. PMC 4778976. PMID 26897901.
- ↑ Lou, YL; Botelho, MG; Darvell, BWD (2012). "Erratum to "Reaction of silver diammine fluoride with hydroxyapatite and protein" [J. Dent. 39 (2011) 612–618]". J Dent. 40 (1): 91–93. doi:10.1016/j.jdent.2011.10.009.