Spondin 2

SPON2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPON2, DIL-1, DIL1, M-SPONDIN, MINDIN, spondin 2
External IDsMGI: 1923724 HomoloGene: 40843 GeneCards: SPON2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p16.3Start1,166,932 bp[1]
End1,208,962 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10417

100689

Ensembl

ENSG00000159674

ENSMUSG00000037379

UniProt

Q9BUD6

Q8BMS2

RefSeq (mRNA)

NM_012445
NM_001128325
NM_001199021

NM_133903

RefSeq (protein)

NP_001121797
NP_001185950
NP_036577

NP_598664

Location (UCSC)Chr 4: 1.17 – 1.21 MbChr 5: 33.2 – 33.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159674 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037379 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Spondin 2, extracellular matrix protein".

Further reading

  • Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H (October 2011). "Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling". Cardiovascular Research. 92 (1): 85–94. doi:10.1093/cvr/cvr159. PMC 3657538. PMID 21632881.
  • Qian X, Li C, Pang B, Xue M, Wang J, Zhou J (2012). "Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker". PLoS One. 7 (5): e37225. doi:10.1371/journal.pone.0037225. PMC 3352876. PMID 22615945.
  • Feinstein Y, Klar A (June 2004). "The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities". The International Journal of Biochemistry & Cell Biology. 36 (6): 975–80. doi:10.1016/j.biocel.2004.01.002. PMID 15094111.
  • Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA (February 2009). "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule". The EMBO Journal. 28 (3): 286–97. doi:10.1038/emboj.2008.288. PMC 2637340. PMID 19153605.
  • Liao CH, Yeh SC, Huang YH, Chen RN, Tsai MM, Chen WJ, Chi HC, Tai PJ, Liao CJ, Wu SM, Cheng WL, Pai LM, Lin KH (March 2010). "Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion". Endocrine-Related Cancer. 17 (1): 99–111. doi:10.1677/ERC-09-0050. PMID 19903741.
  • Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Takagi M, Horikoshi S, Tomino Y (July 2011). "Mindin: a novel marker for podocyte injury in diabetic nephropathy". Nephrology, Dialysis, Transplantation. 26 (7): 2153–60. doi:10.1093/ndt/gfq708. PMID 21098016.
  • Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (October 1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675.
  • Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP (March 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
  • Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K (March 2008). "Sequence variants in the RNF212 gene associate with genome-wide recombination rate". Science. 319 (5868): 1398–401. doi:10.1126/science.1152422. PMID 18239089.


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